欢迎各位来到“circRNA研究报道汇总”栏目,本期从pubmed中检索收集最新发布的circRNA文献共计63篇,下面我们一起来看看,circRNA研究最近有哪些新进展。
检索式:(circRNA[Title/Abstract]) OR Circular RNA[Title/Abstract]
1、RNA出核因子Nxt1在确保果蝇肌肉完整性和正常RNA表达中的作用
标题:Roles for RNA export factor, Nxt1, in ensuring muscle integrity and normal RNA expression in Drosophila
杂志:G (Bethesda). 影响因子:2.781
通讯作者:Helen White-Cooper(英国卡迪夫大学)
mRNA输出途径负责将mRNA从细胞核转运到细胞质,因此对于蛋白质生产和正常的细胞功能至关重要。果蝇中mRNA出核因子Nxt1的等位基因部分功能丧失,则表现为个体活力降低和不育性。先前的研究表明,雄性不育性缺陷是由于转录和RNA稳定性缺陷所致,表明mRNA输出途径可能与已知的mRNA转运功能有关。在这里,研究者研究了Nxt1功能突变体,果蝇个体活力降低,并描述了幼虫肌肉生长和维持中的缺陷,导致肌肉变性。 RNA-seq测序结果揭示了一组mRNA的表达减少,尤其是来自Nxt1突变体尸体中具有长内含子的基因的表达。研究者还检测到circRNA的差异表达,并且突变体中表达的不同circRNA明显更少。尽管基因表达存在广泛的缺陷,但肌肉中的costamere component tn (abba)的表达增加可以挽救肌肉变性。这是mRNA出核途径基因Nxt1在维持肌肉完整性中的作用的首次报道。该研究数据还将mRNA输出途径与体内常见前体基因的mRNA和circRNA表达中的特定作用联系起来。
2、TTN环状RNA创建了SRSF10剪接必不可少的反向剪接基序。
标题:TTN Circular RNAs Create A Backsplice Motif Essential for SRSF10 Splicing
杂志:Circulation. 影响因子:23.603
通讯作者:Anke J. Tijsen(阿姆斯特丹大学医学院)
研究背景:人类中最大的蛋白质Titin(TTN)形成分子弹簧,该分子弹簧跨越了整个肌小节的一半,为心肌细胞提供了被动的弹性。中断TTN转录的突变是遗传性心力衰竭的最常见原因。我们之前证明了TTN产生一类依赖于RBM20形成的环状RNA(circRNA)。在这项研究中,我们表明由此类circRNA形成的反向剪接连接产生了独特的基序,该基序与SRSF10结合以使其能够调节剪接。此外,我们显示这些circRNA(cTTN1)之一扭曲了RBM20的定位和剪接。研究方法:我们计算了从gnomAD数据库收集的125.748个外显子组中识别出的基序的遗传限制。此外,我们专注于人类心脏中表达最高的RBM20依赖性circRNA,我们将其命名为cTTN1。我们使用针对后剪接点的shRNA,在人诱导的多能干细胞衍生的心肌细胞(hiPSC-CM)中诱导cTTN1的选择性丢失。研究结果:人类遗传学提示所生成基序的遗传耐受性降低,表明该基序中的突变可能导致疾病。RNA免疫沉淀证实具有此基序的circRNA与SRSF10结合。hiPSC-CM中cTTN1的选择性缺失导致工程心脏组织中的结构异常,凋亡和收缩力降低。与其SRSF10结合相符,cTTN1的缺失导致重要的心肌细胞SRSF10靶标(如MEF2A和CASQ2)的异常剪接。令人惊讶的是,cTTN1的丢失也引起TTN本身的异常剪接。从机制上讲,我们表明cTTN1的丢失会扭曲RBM20的定位和剪接。结论:我们证明了由TTN形成的circRNA通过启用剪接调节子RBM20和SRSF10,转录本对于关键肌肉基因的正常剪接至关重要。这表明,TTN转录本除了其众所周知的信号传导和结构功能外,还具有调节作用。此外,我们证明了由这些circRNA的反向剪接连接产生的特定序列具有重要功能。这突出了功能上重要的序列的存在,这些序列在人类基因组中无法被识别,但为功能序列变异提供了一个尚未被认识的来源。
3、CircTulp4通过调节其亲本基因Tulp4在阿尔茨海默氏病发病机理中发挥作用
标题:CircTulp4 functions in Alzheimer’s disease pathogenesis by regulating its parental gene, Tulp4
杂志:Mol Ther. 影响因子:8.986
通讯作者:Jun Wan和Wei Zhang(深圳湾实验室)
阿尔茨海默氏病(AD)是全球最常见的神经退行性疾病之一,会损害人类认知,记忆和语言能力,并导致痴呆。但是,AD的发病机理仍然不清楚。最近,人们发现了AD与环状RNA(circRNA)之间的潜在联系,但仅发现了可能与AD相关的少数circRNA。在这里,我们通过高通量RNA测序系统研究APP/PS1模型小鼠大脑中的circRNA。我们报告说,circRNAs在大脑中明显富集,并且几种circRNAs在野生型和APP/PS1小鼠之间表现出差异表达。我们表征了一种丰富的circRNA,circTulp4,其衍生自基因Tulp4的Intron1。我们的结果表明,circTulp4主要位于细胞核中,并与U1 snRNP和RNA聚合酶II相互作用,以调节其亲本基因Tulp4的转录,从而调节神经系统的功能,并可能参与AD的发展。
图注:CircTulp4通过调节其亲本基因Tulp4在阿尔茨海默氏病作用机理示意图
文献列表:
序号 |
主要内容 |
论文标题 |
杂志 |
IF |
单位 |
1 |
RNA出核因子Nxt1在确保果蝇肌肉完整性和正常RNA表达中的作用 |
Roles for RNA export factor, Nxt1, in ensuring muscle integrity and normal RNA expression in Drosophila |
G (Bethesda). |
2.781 |
英国卡迪夫大学等 |
2 |
TTN环状RNA创建了SRSF10剪接必不可少的反向剪接基序。 |
TTN Circular RNAs Create A Backsplice Motif Essential for SRSF10 Splicing |
Circulation. |
23.603 |
阿姆斯特丹大学医学院等 |
3 |
CircTulp4通过调节其亲本基因Tulp4在阿尔茨海默氏病发病机理中发挥作用 |
CircTulp4 functions in Alzheimer’s disease pathogenesis by regulating its parental gene, Tulp4 |
Mol Ther. |
8.986 |
深圳湾实验室等 |
4 |
骨肉瘤中的非编码RNA:对耐药性的影响 |
Noncoding RNAs in osteosarcoma: Implications for drug resistance |
Cancer Lett. |
7.36 |
中南大学湘雅第二医院等 |
5 |
环状RNA在哺乳动物脑中的表达和功能 |
Expression and function of circular RNAs in the mammalian brain |
Cell Mol Life Sci.Review |
6.496 |
中国科学院昆明动物研究所等 |
6 |
环状RNA circ_103820通过使miR-200b-3p海绵化释放LATS2和SOCS6抑制肺癌的发生 |
Circular RNA circ_103820 suppresses lung cancer tumorigenesis by sponging miR-200b-3p to release LATS2 and SOCS6 |
Cell Death Dis. |
6.304 |
上海市浦东新区公利医院等 |
7 |
circST6GALNAC6通过海绵化miR-200a-3p调节STMN1/EMT轴来抑制膀胱癌的转移 |
circST6GALNAC6 suppresses bladder cancer metastasis by sponging miR-200a-3p to modulate the STMN1/EMT axis |
Cell Death Dis. |
6.304 |
中南大学湘雅第二医院等 |
8 |
综述:环状RNA及其对癌症作用的新见解 |
Review on circular RNAs and new insights into their roles in cancer |
Comput Struct Biotechnol J.Review |
6.018 |
南京市中医院等 |
9 |
环状RNA circHECTD1通过调节miR-296-3p/SLC10A7轴促进神经胶质瘤进展 |
Circular RNA circHECTD1 facilitates glioma progression by regulating the miR-296-3p/SLC10A7 axis |
J Cell Physiol. |
5.546 |
哈尔滨医科大学附属肿瘤医院等 |
10 |
长和短的非编码RNA和放射应答:综述 |
Long and short non-coding RNA and radiation response: a review |
Transl Res.Review |
5.411 |
美国国家癌症研究所等 |
11 |
表观遗传学调控在骨代谢和骨质疏松中的作用 |
The Roles of Epigenetics Regulation in Bone Metabolism and Osteoporosis |
Front Cell Dev Biol.Review |
5.201 |
上海中医药大学附属曙光医院等 |
12 |
环状RNA CircCOL5A1海绵化MiR-7-5p/Epac1轴调节PI3K/Akt信号通路从而促进瘢痕loid的进程 |
Circular RNA CircCOL5A1 Sponges the MiR-7-5p/Epac1 Axis to Promote the Progression of Keloids Through Regulating PI3K/Akt Signaling Pathway |
Front Cell Dev Biol. |
5.201 |
武汉同济医院等 |
13 |
基于环状RNA相关竞争内源RNA机制的术后乳头状甲状腺癌进展风险评估 |
Progression Risk Assessment of Post-surgical Papillary Thyroid Carcinoma Based on Circular RNA-Associated Competing Endogenous RNA Mechanisms |
Front Cell Dev Biol. |
5.201 |
北京协和医院等 |
14 |
Circ-AASDH通过靶向miR-140-3p激活E2F7表达,可作为早期肺腺癌的进展 |
Circ-AASDH functions as the progression of early stage lung adenocarcinoma by targeting miR-140-3p to activate E2F7 expression |
Transl Lung Cancer Res. |
5.132 |
青岛大学医学院附属医院等 |
15 |
环形RNA TTC3通过miR-372-3p/TLR4轴调节脑梗死中的脑缺血-再灌注损伤和神经干细胞 |
Circular RNA TTC3 regulates cerebral ischemia-reperfusion injury and neural stem cells by miR-372-3p/TLR4 axis in cerebral infarction |
Stem Cell Res Ther. |
5.116 |
锦州医科大学附属第一医院等 |
16 |
Sebastes schlegelii Following Edwardsiella tarda Challenge肠中的circRNA-miRNA-mRNA调控网络的综合分析。 |
Integrated Analysis of circRNA-miRNA-mRNA Regulatory Networks in the Intestine of Sebastes schlegelii Following Edwardsiella tarda Challenge |
Front Immunol. |
5.085 |
青岛农业大学等 |
17 |
CircRNA作为骨髓增生异常综合征患者新型生物标志物和潜在功能性CeRNA网络的鉴定 |
Identification of CircRNA as Novel Biomarkers and potentially Functional CeRNA Network for Myelodysplastic syndrome patients |
Cancer Sci. |
4.966 |
复旦大学附属华山医院等 |
18 |
全基因组的环状RNA的分布,剪接和R-环在毛果杨的茎分化木质部中的分布 |
Genome-wide profiling of circular RNAs, alternative splicing, and R-loops in stem-differentiating xylem of Populus trichocarpa |
J Integr Plant Biol. |
4.885 |
福建农林大学等 |
19 |
环状RNA circ_0014717通过调节miR-668-3p/BTG2轴抑制肝细胞癌的发生 |
Circular RNA circ_0014717 Suppresses Hepatocellular Carcinoma Tumorigenesis Through Regulating miR-668-3p/BTG2 Axis |
Front Oncol. |
4.848 |
右江民族医学院附属医院等 |
20 |
Hsa_circ_0107593通过海绵化hsa-miR-20a-5p/93-5p/106b-5p抑制宫颈癌的进展 |
Hsa_circ_0107593 Suppresses the Progression of Cervical Cancer via Sponging hsa-miR-20a-5p/93-5p/106b-5p |
Front Oncol. |
4.848 |
广西医科大学附属第一医院等 |
21 |
Circ_0115744作为miR-144海绵来促进和预测结直肠癌的转移 |
Circ_ 0115744 acts as miR-144 sponge to promote and predict the metastasis of colorectal cancer |
Aging (Albany NY). |
4.831 |
苏州大学第二附属医院等 |
22 |
新型鉴定的RCAN2,circ-RCAN2的圆形转录本,在猪再灌注的梗死心肌和缺氧性猪心脏祖细胞中显示出偏离的表达模式 |
Novel Identified Circular Transcript of RCAN2, circ-RCAN2, Shows Deviated Expression Pattern in Pig Reperfused Infarcted Myocardium and Hypoxic Porcine Cardiac Progenitor Cells In Vitro |
Int J Mol Sci. |
4.556 |
维也纳医科大学等 |
23 |
环状RNA在结直肠肿瘤微环境中的作用 |
Role of circular RNAs in colorectal tumor microenvironment |
Biomed Pharmacother.Review |
4.545 |
英国索尔福德大学等 |
24 |
环状RNA CDR1as通过调节胰腺癌中的miR-432-5p/E2F3轴促进肿瘤进展 |
Circular RNA CDR1as promotes tumor progression by regulating miR-432-5p/E2F3 axis in pancreatic cancer |
Cancer Cell Int. |
4.175 |
武汉大学人民医院等 |
25 |
Circ_0004872通过miR-513a-5p/TXNIP轴促进血小板衍生的生长因子-BB诱导的HA-VSMC中的增殖,迁移和去分化 |
Circ_0004872 promotes platelet-derived growth factor-BB-induced proliferation, migration and dedifferentiation in HA-VSMCs via miR-513a-5p/TXNIP axis |
Vascul Pharmacol. |
4.152 |
郑州大学第一附属医院等 |
26 |
环状RNA cIARS通过与RNA结合蛋白ALKBH5相互作用调节HCC细胞中的肥大症 |
Circular RNA cIARS regulates ferroptosis in HCC cells through interacting with RNA binding protein ALKBH5 |
Cell Death Discov. |
4.114 |
山东省千佛山医院等 |
27 |
非编码RNA在上皮癌中的作用 |
The role of noncoding RNAs in epithelial cancer |
Cell Death Discov.Review |
4.114 |
英国剑桥大学等 |
28 |
circRNA翻译中的信号和噪声 |
Signal and noise in circRNA translation |
Methods. |
3.812 |
丹麦奥尔胡斯大学等 |
29 |
从非聚腺苷酸化RNA-seq数据集进行circRNA注释和定量的CIRCexplorer管道 |
CIRCexplorer pipelines for circRNA annotation and quantification from non-polyadenylated RNA-seq datasets |
Methods. |
3.812 |
中国科学院上海营养与健康研究所等 |
30 |
使用无酶数字计数方法分析circRNA |
Profiling of circRNAs using an enzyme-free digital counting method |
Methods. |
3.812 |
丹麦奥尔胡斯大学等 |
31 |
检测纯化的剪接体P复合物中的circRNA |
Detecting circRNA in purified spliceosomal P complex |
Methods. |
3.812 |
科罗拉多大学安舒茨医学分校等 |
32 |
通过SHAPE-MaP绘制活细胞中的环状RNA结构图 |
Mapping circular RNA structures in living cells by SHAPE-MaP |
Methods. |
3.812 |
中国科学院生物化学与细胞生物学研究所等 |
33 |
非编码RNA在中枢神经系统轴突再生中的作用。 |
Roles of Non-coding RNAs in Central Nervous System Axon Regeneration |
Front Neurosci.Review |
3.707 |
中国医科大学附属盛京医院等 |
34 |
circRNA在乳头状甲状腺癌的发生发展中的作用 |
Advances on circRNAs Contribute to Carcinogenesis and Progression in Papillary Thyroid Carcinoma |
Front Endocrinol (Lausanne).Review |
3.644 |
山西省肿瘤医院等 |
35 |
circRNA_000684的抑制通过miR-145介导的KLF5抑制胰腺导管腺癌细胞的恶性表型 |
Repression of circRNA_000684 inhibits malignant phenotypes of pancreatic ductal adenocarcinoma cells via miR-145-mediated KLF5 |
Pancreatology. |
3.629 |
吉林大学第二医院等 |
36 |
弥漫性大B细胞淋巴瘤中循环RNA生物标志物:系统评价 |
Circulating RNA biomarkers in diffuse large B-cell lymphoma: a systematic review |
Exp Hematol Oncol.Review |
3.492 |
比利时根特大学等 |
37 |
新型环状RNA circ-PGAP3通过调节miR-769-5p/p53轴来延迟宫颈癌的生长 |
The novel circular RNA circ-PGAP3 retards cervical cancer growth by regulating the miR-769-5p/p53 axis |
Hum Cell. |
3.463 |
河南大学淮河医院等 |
38 |
使用非编码RNA治疗糖尿病性心肌病的现状和潜在的治疗策略 |
Current Status and Potential Therapeutic Strategies for Using Non-coding RNA to Treat Diabetic Cardiomyopathy |
Front Physiol.Review |
3.367 |
美国俄亥俄州立大学等 |
39 |
Circ SMARCA5通过与SND1相互作用并下调YWHAB基因在宫颈癌中抑制肿瘤转移 |
Circ SMARCA5 Inhibited Tumor Metastasis by Interacting with SND1 and Downregulating the YWHAB Gene in Cervical Cancer |
Cell Transplant. |
3.341 |
郑州大学第二附属医院等 |
40 |
CircRNA Circ-ITCH通过靶向miR-106a-5p/SASH1轴抑制胶质瘤细胞的增殖和侵袭 |
CircRNA Circ-ITCH Inhibits the Proliferation and Invasion of Glioma Cells Through Targeting the miR-106a-5p/SASH1 Axis |
Cell Transplant. |
3.341 |
南京市第一医院等 |
41 |
环状RNA circARPP21充当miR-543的海绵,通过调节LIFR抑制肝细胞癌 |
Circular RNA circARPP21 Acts as a Sponge of miR-543 to Suppress Hepatocellular Carcinoma by Regulating LIFR |
Onco Targets Ther. |
3.337 |
江苏省人民医院等 |
42 |
槲皮素治疗宫颈癌候选基因的筛选及其调控网络分析 |
Screening of Therapeutic Candidate Genes of Quercetin for Cervical Cancer and Analysis of Their Regulatory Network |
Onco Targets Ther. |
3.337 |
陕西中医药大学第二附属医院等 |
43 |
环状RNA circ_104640在早期肺腺癌中的作用和机制:潜在的诊断和治疗靶点 |
The roles and mechanisms of the circular RNA circ_104640 in early-stage lung adenocarcinoma: a potential diagnostic and therapeutic target |
Ann Transl Med. |
3.297 |
苏州大学附属第一医院等 |
44 |
环状RNA circANKS1B充当miR-152-3p的海绵,并通过上调TGF-α表达来促进前列腺癌的进展 |
Circular RNA circANKS1B acts as a sponge for miR-152-3p and promotes prostate cancer progression by upregulating TGF-伪 expression |
Prostate. |
3.279 |
安徽医科大学第一附属医院等 |
45 |
实验性颞叶癫痫向复发性自发性癫痫的转变中环状RNA表达失调富集 |
Enrichment of Circular RNA Expression Deregulation at the Transition to Recurrent Spontaneous Seizures in Experimental Temporal Lobe Epilepsy |
Front Genet. |
3.258 |
荷兰乌得勒支大学等 |
46 |
重度急性胰腺炎小鼠lncRNA,circRNA和mRNA差异表达及其ceRNA网络的综合分析 |
Comprehensive Analysis of Differentially Expressed lncRNA, circRNA and mRNA and Their ceRNA Networks in Mice With Severe Acute Pancreatitis |
Front Genet. |
3.258 |
中国人民解放军西部战区总医院等 |
47 |
与前列腺癌相关的代谢途径中的五个环状RNA |
Five Circular RNAs in Metabolism Pathways Related to Prostate Cancer |
Front Genet. |
3.258 |
北京医院国家老年医学中心等 |
48 |
DeCban:使用双嵌入和跨分支网络预测circRNA-RBP相互作用位点 |
DeCban: Prediction of circRNA-RBP Interaction Sites by Using Double Embeddings and Cross-Branch Attention Networks |
Front Genet. |
3.258 |
上海交通大学等 |
49 |
环状RNA hsa_circ_0007534的下调通过调节骨肉瘤中的miR-219a-5p/SOX5轴抑制细胞生长 |
Down-regulation of circular RNA hsa_circ_0007534 suppresses cell growth by regulating miR-219a-5p/SOX5 axis in osteosarcoma |
J Bone Oncol. |
3.066 |
襄阳市中心医院等 |
50 |
环状RNA circANKIB1通过调节miR-217/PAX3轴促进骨肉瘤的进展 |
Circular RNA circANKIB1 promotes the progression of osteosarcoma by regulating miR-217/PAX3 axis |
J Bone Oncol. |
3.066 |
宁夏医科大学总医院等 |
51 |
丙泊酚通过靶向circVPS13C/miR-145轴抑制MEK/ERK信号传导,从而抑制卵巢癌细胞的生存能力,细胞周期进程和运动能力,并诱导卵巢癌细胞凋亡 |
Propofol suppresses cell viability, cell cycle progression and motility and induces cell apoptosis of ovarian cancer cells through suppressing MEK/ERK signaling via targeting circVPS13C/miR-145 axis |
J Ovarian Res. |
2.989 |
福建省妇幼保健院等 |
52 |
circ_SLIT3/miR-223-3p/CXCR4轴对Celastrol对肝细胞癌的抗肿瘤作用 |
Anti-Tumor Effect of Celastrol on Hepatocellular Carcinoma by the circ_SLIT3/miR-223-3p/CXCR4 Axis |
Cancer Manag Res. |
2.886 |
陕西中医药大学附属医院等 |
53 |
CircRNA ZNF609沉默通过miR-623/FOXM1轴抑制非小细胞肺癌的发展 |
CircRNA ZNF609 Knockdown Represses the Development of Non-Small Cell Lung Cancer via miR-623/FOXM1 Axis |
Cancer Manag Res. |
2.886 |
淄博市第四人民医院等 |
54 |
Hsa_circ_0043278在大肠癌中抑制肿瘤发生并下调 |
Hsa_circ_0043278 Inhibits Tumorigenesis and is Downregulated in Colorectal Cancer |
Cancer Manag Res. |
2.886 |
宁波大学医学院附属医院等 |
55 |
外泌体circ_PIP5K1A通过miR-101/ABCC1轴调控非小细胞肺癌的进展和顺铂敏感性 |
Exosomal circ_PIP5K1A regulates the progression of non-small cell lung cancer and cisplatin sensitivity by miR-101/ABCC1 axis |
Mol Cell Biochem. |
2.795 |
山东省立医院等 |
56 |
与健康对照组相比,颅内动脉瘤组差异表达的环状RNA谱。 |
Differentially Expressed Circular RNA Profile in an Intracranial Aneurysm Group Compared with a Healthy Control Group |
Dis Markers. |
2.738 |
北京天坛医院 |
57 |
circRNA的编码潜力:新发现和新挑战 |
Coding potential of circRNAs: new discoveries and challenges |
PeerJ. |
2.379 |
中国人民解放军联勤保障部队第901医院等 |
58 |
非编码circ-SHPRH编码的隐藏肽SHPRH-146aa的结构表征,以作为肿瘤抑制因子 |
Structural Characterization of the Hidden Peptide SHPRH-146aa Encoded by Non-Coding circ-SHPRH to Act as Tumor Suppressor |
Appl Biochem Biotechnol. |
2.277 |
印度卡利亚尼大学等 |
59 |
CircPPP1R12A通过刺激miR-375调节CTNNB1促进结肠癌的发展 |
CircPPP1R12A promotes the progression of colon cancer through regulating CTNNB1 via sponging miR-375 |
Anticancer Drugs. |
2.26 |
荆门市第一人民医院等 |
60 |
环状RNA谱和hsa_circ_0001360表达下调可能与皮肤鳞状细胞癌的发生有关 |
Circular RNA profiles and the potential involvement of down-expression of hsa_circ_0001360 in cutaneous squamous cell carcinogenesis |
FEBS Open Bio. |
2.231 |
广东省皮肤病防治研究所等 |
61 |
NFIB通过上调circMAP7D1稳定HER2 mRNA促进胃癌的发展 |
NFIB promotes the progression of gastric cancer by聽upregulating circMAP7D1 to stabilize HER2 mRNA |
Mol Med Rep. |
2.1 |
重庆市肿瘤医院等 |
62 |
Circ_0000735通过调节miR-635/FAM83F轴增强非小细胞肺癌的增殖,转移和糖酵解 |
Circ_0000735 enhances the proliferation, metastasis and glycolysis of non-small cell lung cancer by regulating the miR-635/FAM83F axis |
Exp Lung Res. |
1.702 |
江苏省盱眙县人民医院等 |
63 |
阐明冠状动脉疾病的表观遗传景观:个性化医学的基本概念综述。 |
Elucidation of Epigenetic Landscape in Coronary Artery Disease: A Review on Basic Concept to Personalized Medicine |
Epigenet Insights Review |
0 |
印度德里大学等 |