欢迎各位来到“circRNA研究报道汇总”栏目,本期从pubmed中检索收集最新发布的circRNA文献共计69篇,下面我们一起来看看,circRNA研究最近有哪些新进展。

检索式:(circRNA[Title/Abstract]) OR Circular RNA[Title/Abstract]

 

1、蛋白质诱饵假说:circRNA编码的蛋白质竞争性抑制同源功能同工型。

标题:Protein Bait Hypothesis: circRNA-Encoded Proteins Competitively Inhibit Cognate Functional Isoforms

杂志:Trends Genet.影响因子:11.333

通讯作者:李笑天教授(复旦大学附属妇产科医院)

 

已经证明某些circRNA可以编码肽,即这些环状RNA应重新定义为编码转录本。我们提出蛋白质诱饵假说来描述circRNA编码的蛋白质的功能机制。circRNA编码的蛋白具有独特的特征,例如与mRNA编码的同工型具有高序列同源性,且长度短,从而使其可以作为诱饵与同类蛋白的伴侣竞争性结合。蛋白质诱饵假说可用于解释各种生物学现象,并针对不同的病理生理事件设计治疗性干预措施。最近的研究表明,环状RNA(circRNA)编码的大量蛋白质可能在癌症发展中发挥作用。但是,我们对这组蛋白质及其所涉及的功能机制的理解仍然存在很大差距。因此,我们提出了蛋白质诱饵假说,该假说指定了circRNA编码的蛋白质与它们的同源线性剪接的蛋白质同工型竞争结合分子,从而阻止了适当的同工型功能。该假设可能会扩展我们对circRNA编码蛋白功能机制的理解,并被证明有助于阐明人类发育,生理学和疾病的潜在机制,同时也有助于药物开发。

 

图注:circRNA蛋白质诱饵假说示意图

2、聚焦非编码RNA与自噬在结直肠癌中的作用

标题:The Role of non-coding RNAs in colorectal cancer, with a focus on its autophagy

杂志:Pharmacol Ther.  影响因子:10.557

通讯作者:徐海波和孟宪丽教授 (成都中医药大学)

 

大肠癌(CRC)是全世界人民的恶性疾病之一,主要是由于缺乏有效的医疗干预措施以及对CRC发病机理的机制理解不足所致。非编码RNA(ncRNA)是一类异源转录本,不具有编码蛋白质的能力,但具有调节蛋白质编码基因表达的能力。自噬是一种进化上保守的分解代谢过程,其中细胞质内容物被递送至细胞溶酶体进行降解,从而导致细胞成分的周转并产生细胞功能所需的能量。越来越多的证据表明,ncRNA,自噬以及ncRNA与自噬的串扰在CRC的起始、进展、转移、复发和治疗抗性中起着复杂的作用,这赋予ncRNA和自噬作为CRC临床生物标志物和治疗靶点。在这篇综述中,我们试图描述ncRNA在CRC发病机理中的复杂作用,主要包括miRNA,lncRNA和circRNA,特别是着眼于ncRNA在CRC相关自噬中的调控作用,试图阐明复杂的病理机制,涉及ncRNA和自噬,负责CRC肿瘤的发生和发展,从而为临床环境中基于ncRNA和自噬的CRC治疗策略奠定基础。

图注:ncRNA在CRC中的调控作用

 

3、环状RNA在胰腺癌中的不同作用

标题:The diverse roles of circular RNAs in pancreatic cancer

杂志:Pharmacol Ther. 影响因子:10.557

通讯作者:沈贤教授(温州医科大学附属第二医院)

 

胰腺癌是预后较差的恶性肿瘤之一。 胰腺癌发生和恶性进展的分子机制尚未完全阐明。 几个关键的信号传导途径,如Notch,Wnt和Hedgehog途径,对于促进胰腺癌的发生很重要。 近来,非编码RNA,特别是环状RNA(circRNA),已被表征为参与胰腺癌的发展。 因此,在这篇综述文章中,我们描述了circRNA与胰腺癌预后之间的关联。 此外,我们讨论了circRNA如何参与胰腺癌细胞过程的调控,包括增殖、凋亡、细胞周期、迁移、侵袭、EMT、转移、血管生成、耐药性和免疫逃逸。 此外,我们提到了几种化合物可以调节circRNA的表达,这表明通过化合物靶向circRNA可能有助于治疗胰腺癌患者。

图注:circRNA在胰腺癌中的调控作用

文献列表:

序号

主要内容

论文标题

杂志

IF

单位

1

蛋白质诱饵假说:circRNA编码的蛋白质竞争性抑制同源功能同工型。

Protein Bait Hypothesis: circRNA-Encoded Proteins Competitively Inhibit Cognate Functional Isoforms

Trends Genet.

11.333

复旦大学附属妇产科医院等

2

聚焦非编码RNA与自噬在结直肠癌中的作用

The Role of non-coding RNAs in colorectal cancer, with a focus on its autophagy

Pharmacol Ther.

10.557

成都中医药大学等

3

环状RNA在胰腺癌中的不同作用

The diverse roles of circular RNAs in pancreatic cancer

Pharmacol Ther.

10.557

温州医科大学附属第二医院等

4

环状RNA对自噬和疾病进展的影响

The influence of circular RNAs on autophagy and disease progression

Autophagy.

9.77

中南大学等

5

NSL2CD:基于网络嵌入和子空间学习识别潜在的circRNA-疾病关联

NSL2CD: identifying potential circRNA-disease associations based on network embedding and subspace learning

Brief Bioinform.

8.99

湖南大学等

6

环状RNA circZbtb20通过Nr4a1 mRNA的Alkbh5依赖性m(6)A去甲基化维持ILC3稳态和功能

Circular RNA circZbtb20 maintains ILC3 homeostasis and function via Alkbh5-dependent m(6)A demethylation of Nr4a1 mRNA

Cell Mol Immunol.

8.484

中国科学院大学等

7

hsa_circ_0001018通过促进细胞存活,侵袭,G(1)/ S细胞周期进程以及通过与miR-338-3p和SOX4的串扰抑制细胞凋亡来促进甲状腺乳头状癌

hsa_circ_0001018 promotes papillary thyroid cancer by facilitating cell survival, invasion, G(1)/S cell cycle progression, and repressing cell apoptosis via crosstalk with miR-338-3p and SOX4

Mol Ther Nucleic Acids.

7.032

吉林大学中日联谊医院等

8

环状RNA hsa_circ_0006401促进结直肠癌的增殖和转移

Circular RNA hsa_circ_0006401 promotes proliferation and metastasis in colorectal carcinoma

Cell Death Dis.

6.304

浙江省人民医院等

9

肿瘤来源的外泌体circPSMA1通过miR-637 / Akt1 /β-catenin(cyclin D1)轴促进三阴性乳腺癌(TNBC)的肿瘤发生,转移和迁移

Tumor-derived exosomal circPSMA1 facilitates the tumorigenesis, metastasis, and migration in triple-negative breast cancer (TNBC) through miR-637/Akt1/尾-catenin (cyclin D1) axis

Cell Death Dis.

6.304

江苏省人民医院等

10

CircEHD2,CircNETO2和CircEGLN3作为肾细胞癌患者的诊断和预后生物标志物

CircEHD2, CircNETO2 and CircEGLN3 as Diagnostic and Prognostic Biomarkers for Patients with Renal Cell Carcinoma

Cancers (Basel).

6.126

德国波恩大学等

11

Chemonaive淋巴结阴性结肠癌患者的环状RNA

Circular RNA in Chemonaive Lymph Node Negative Colon Cancer Patients

Cancers (Basel).

6.126

荷兰鹿特丹大学等

12

CircSLC7A2通过抑制miR-4498 / TIMP3轴来预防骨关节炎

CircSLC7A2 protects against osteoarthritis through inhibition of the miR-4498/TIMP3 axis

Cell Prolif.

5.753

浙江邵逸夫医院等

13

iCircDA-LTR:基于学习排名确定circRNA-疾病关联

iCircDA-LTR: identification of circRNA-disease associations based on Learning to Rank

Bioinformatics.

5.61

北京大学等

14

新型circGFRα1促进由m6A METL14介导的女性生殖干细胞的自我更新

Novel circGFR伪1 Promotes Self-Renewal of Female Germline Stem Cells Mediated by m(6)A Writer METTL14

Front Cell Dev Biol.

5.201

宁夏医科大学等

15

SOX9转录因子与微小RNA在癌症中的相互作用

Interplay between SOX9 transcription factor and microRNAs in cancer

Int J Biol Macromol.

5.162

南非约翰内斯堡大学

16

胃肠道肿瘤中环状RNA的研究进展

Research Progress of Circular RNA in Gastrointestinal Tumors

Front Oncol.

4.848

江苏大学附属人民医院等

17

环状RNA hsa_circ_0013958通过调节miR-532-3p / WEE1轴在肝细胞癌中作为致癌基因。

Circular RNA hsa_circ_0013958 Functions as an Oncogenic Gene Through Modulating miR-532-3p/WEE1 Axis in Hepatocellular Carcinoma

Front Oncol.

4.848

武汉协和医院等

18

Circ-ZFR通过海绵吸附miR-545和miR-1270上调WNT5A来促进膀胱癌的进展。

Circ-ZFR Promotes Progression of Bladder Cancer by Upregulating WNT5A Via Sponging miR-545 and miR-1270

Front Oncol.

4.848

西南医科大学等

19

环状RNA和肝细胞癌:具有诊断和预后作用的新表观遗传参与者。

Circular RNAs and Hepatocellular Carcinoma: New Epigenetic Players With Diagnostic and Prognostic Roles

Front Oncol.

4.848

上海医药卫生大学等

20

与子宫内膜异位症相关的外泌体circRNA-miRNA-mRNA调控网络的构建和拓扑分析

Construction and topological analysis of an endometriosis-related exosomal circRNA-miRNA-mRNA regulatory network

Aging (Albany NY).

4.831

中南大学湘雅第二医院等

21

环状RNA circitga7通过miR-34a-5p / VEGFA轴加速神经胶质瘤的进展

Circular RNA circitga7 accelerates glioma progression via miR-34a-5p/VEGFA axis

Aging (Albany NY).

4.831

吉林大学第一医院等

22

非小细胞肺癌中肿瘤来源的外泌体circRNA_102481通过miR-30a-5p / ROR1轴促进EGFR-TKIs耐药

Tumor-derived exosomal circRNA_102481 contributes to EGFR-TKIs resistance via the miR-30a-5p/ROR1 axis in non-small cell lung cancer

Aging (Albany NY).

4.831

吉林大学第一医院等

23

肝细胞癌中circHIPK3吸附miR-124-3p / miR-4524-5p调控MRP4表达。

Regulation of MRP4 Expression by circHIPK3 via Sponging miR-124-3p/miR-4524-5p in Hepatocellular Carcinoma

Biomedicines.

4.717

浙江大学等

24

环状RNA在牙周组织和细胞中的新兴调控作用。

The Emerging Regulatory Role of Circular RNAs in Periodontal Tissues and Cells

Int J Mol Sci.

4.556

昆士兰大学等

25

非编码RNA在谷胱甘肽神经保护作用中的作用。

The Role of Non-Coding RNAs in the Neuroprotective Effects of Glutathione

Int J Mol Sci.

4.556

帝京大学医学院等

26

非编码RNA:术后神经认知障碍的新颖见解。

Noncoding RNAs: Novel Insights into Postoperative Neurocognitive Disorders

ACS Chem Neurosci.

4.486

昆明医科大学附属第一医院等

27

复发性植入失败的发病机制中circRNA-miRNA-mRNA网络的构建

Construction of circRNA-miRNA-mRNA network in the pathogenesis of recurrent implantation failure using integrated bioinformatics study

J Cell Mol Med.

4.486

伊朗Hormozgan医科大学等

28

胎儿生长受限(FGR)中的性别相关的lncRNA特征

Sex-Biased lncRNA Signature in Fetal Growth Restriction (FGR)

Cells.

4.366

奥尔什丁瓦尔米亚玛祖里大学等

29

病毒编码的环状RNA在人类致癌病毒致病性中的作用

Role of Virally Encoded Circular RNAs in the Pathogenicity of Human Oncogenic Viruses

Front Microbiol.

4.235

美国杜兰大学等

30

脐静脉内皮细胞与子痫前期的mRNA,circRNA和lncRNA相关的ceRNA网络和潜在的生物标志物的鉴定

Identification of mRNA-, circRNA- and lncRNA- Associated ceRNA Networks and Potential Biomarkers for Preeclampsia From Umbilical Vein Endothelial Cells

Front Mol Biosci.

4.188

国际和平妇幼保健院等

31

circ_NRIP1通过miR-595 / SEMA4D轴和PI3K / AKT途径在食管鳞状细胞癌(ESCC)恶性发展中具有致癌作用

circ_NRIP1 is oncogenic in malignant development of esophageal squamous cell carcinoma (ESCC) via miR-595/SEMA4D axis and PI3K/AKT pathway

Cancer Cell Int.

4.175

河南中医药大学第二附属医院等

32

CircPTK2-miR-181c-5p-HMGB1:败血症诱导的小胶质细胞激活和海马神经元凋亡的新调控途径

CircPTK2-miR-181c-5p-HMGB1: a new regulatory pathway for microglia activation and hippocampal neuronal apoptosis induced by sepsis

Mol Med.

4.096

浙江大学医学院附属第二医院等

33

非编码RNA在人参生锈根部症状组织中的调控作用

Regulatory role of non-coding RNA in ginseng rusty root symptom tissue

Sci Rep.

3.998

吉林农业大学等

34

circ-UQCRC2通过miR-326 / PDCD4 / NF-kb途径抑制减轻脂多糖诱导的MRC-5细胞损伤

Knockdown of circ-UQCRC2 ameliorated lipopolysaccharide-induced injury in MRC-5 cells by the miR-326/PDCD4/NF-kB pathway

Int Immunopharmacol.

3.943

湖北省中医院等

35

环状RNA与心血管再生

Circular RNAs and Cardiovascular Regeneration

Front Cardiovasc Med.

3.915

美国梅奥诊所等

36

使用果蝇模型揭示circRNA的分子和生理功能

Using Drosophila to uncover molecular and physiological functions of circRNAs

Methods.

3.812

布兰迪斯大学等

37

敲低hsa_circ_0134111通过海绵吸附microRNA-224-5p减轻骨关节炎的症状

Knockdown of hsa_circ_0134111 alleviates the symptom of osteoarthritis via sponging microRNA-224-5p

Cell Cycle.

3.699

安徽医科大学附属第一医院等

38

猪骨骼肌中差异表达的circRNA和ceRNA调控网络的综合分析

Comprehensive analysis of differentially expressed circRNAs and ceRNA regulatory network in porcine skeletal muscle

BMC Genomics.

3.594

山西农业大学等

39

CircRNA_0026344通过外泌体miR-21调控Smad7参与香烟烟雾诱导的肺纤维化过程中上皮-成纤维细胞的异常串扰

CircRNA_0026344 via exosomal miR-21 regulation of Smad7 is involved in aberrant cross-talk of epithelium-fibroblasts during cigarette smoke-induced pulmonary fibrosis

Toxicol Lett.

3.569

西南医科大学等

40

下调的hsa_circ_0036988促进口腔鳞状细胞癌的增殖和转移

Downregulated hsa_circ_0036988 promotes proliferation and metastasis in oral squamous cell carcinoma

Cancer Biomark.

3.436

安徽医科大学等

41

沉默circPVT1可通过microRNA-1208增强非小细胞肺癌的放射敏感性

Silencing circPVT1 enhances radiosensitivity in non-small cell lung cancer by sponging microRNA-1208

Cancer Biomark.

3.436

中日友好医院等

42

新型环状RNA circCSPP1通过使miR-1182海绵化促进肝癌的进展

A Novel Circular RNA circCSPP1 Promotes Liver Cancer Progression by Sponging miR-1182

Onco Targets Ther.

3.337

沧州市中心医院等

43

hsa_circ_0000144的耗竭通过调节miR-502-5p / ADAM9轴抑制胃癌细胞的奥沙利铂耐药性

Depletion of hsa_circ_0000144 Suppresses Oxaliplatin Resistance of Gastric Cancer Cells by Regulating miR-502-5p/ADAM9 Axis

Onco Targets Ther.

3.337

皖南医学院弋矶山医院等

44

TCEB3受Circ-0000212 / miR-140-3p轴调控,以促进宫颈癌的进展

TCEB3 is Regulated by Circ-0000212/miR-140-3p Axis to Promote the Progression of Cervical Cancer

Onco Targets Ther.

3.337

潍坊市人民医院等

45

乙烯硫脲诱导的肛门直肠畸形在大鼠胚胎后肠发育过程中环状RNA的RNA-Seq分析。

RNA-Seq Profiling of Circular RNAs During Development of Hindgut in Rat Embryos With Ethylenethiourea-Induced Anorectal Malformations

Front Genet.

3.258

中国医科大学附属盛京医院等

46

子痫前期环状RNA 0004904促进自噬并调节肉瘤/血管内皮生长因子轴中的融合

Circular RNA 0004904 promotes autophagy and regulates the fused in sarcoma/vascular endothelial growth factor axis in preeclampsia

Int J Mol Med.

3.098

四川大学华西医院等

47

CircRNA EPB41L2通过miR-211-5p调节CDH4抑制肺腺癌的致癌性

CircRNA EPB41L2 inhibits tumorigenicity of lung adenocarcinoma through regulating CDH4 by miR-211-5p

Eur Rev Med Pharmacol Sci.

3.024

河南大学淮河医院等

48

基于过表达的可翻译环状RNA的检测容易受到共存的线性RNA副产物的影响

Overexpression-based detection of translatable circular RNAs is vulnerable to coexistent linear RNA byproducts

Biochem Biophys Res Commun.

2.985

深圳大学医学部等

49

环状RNA ciRS-7通过刺激miR-1270激活NF-kb信号通路,影响小隐孢子虫在HCT-8细胞中的繁殖。

Circular RNA ciRS-7 affects the propagation of Cryptosporidium parvum in HCT-8 cells by sponging miR-1270 to activate the NF-kB signaling pathway

Parasit Vectors.

2.824

西北农林科技大学等

50

上调的hsa_circRNA_100269通过使PI3K / Akt轴失活来抑制胃癌的生长和转移

Upregulated hsa_circRNA_100269 inhibits the growth and metastasis of gastric cancer through inactivating PI3K/Akt axis

PLoS One.

2.74

锦州医科大学等

51

LPS诱导的急性肺损伤(ALI)中差异RNA谱和相关竞争性内源RNA网络的全转录组分析

Whole transcriptome analysis of the differential RNA profiles and associated competing endogenous RNA networks in LPS-induced acute lung injury (ALI)

PLoS One.

2.74

四川省肿瘤医院等

52

环状RNA hsa_circ_0091579通过miR-624 / H3F3B轴促进肝细胞癌细胞的Warburg效应和恶性肿瘤

Circular RNA hsa_circ_0091579 facilitates the Warburg effect and malignancy of hepatocellular carcinoma cells via the miR-624/H3F3B axis

Clin Transl Oncol.

2.737

枣庄市中医医院等

53

CircRNA SEPT9通过miR-432-5p介导的LASP1调控促进神经胶质瘤细胞的恶性行为

CircRNA SEPT9 contributes to malignant behaviors of glioma cells via miR-432-5p-mediated regulation of LASP1

Brain Res.

2.733

成都中医药大学等

54

环形RNA circ_0010729组合式敲减可减轻miR-338-3p / CALM2轴对氧葡萄糖剥夺所致的人心肌细胞的伤害

Circular RNA circ_0010729 Knockdown Attenuates Oxygen-Glucose Deprivation-Induced Human Cardiac Myocytes Injury by miR-338-3p/CALM2 Axis

J Cardiovasc Pharmacol.

2.598

沧州市中心医院等

55

通过比较转录组分析鉴定和鉴定与白粉病反应有关的甜瓜环形RNA

Identification and characterization of melon circular RNAs involved in powdery mildew responses through comparative transcriptome analysis

PeerJ.

2.379

山东省农业科学院蔬菜花卉研究所等

56

circCDR1as / miR-641 / XIAP调控轴对前列腺癌PC-3细胞系增殖和侵袭的影响

Effect of the circCDR1as/miR-641/XIAP regulatory axis on the proliferation and invasion of the prostate cancer PC-3 cell line

Oncol Lett.

2.311

苏州大学第二附属医院等

57

Circ_ZFP644通过调节miR-106b / Pias3轴减轻大鼠胰腺腺泡细胞中轻度蛋白诱导的炎性损伤

Circ_ZFP644 attenuates caerulein-induced inflammatory injury in rat pancreatic acinar cells by modulating miR-106b/Pias3 axis

Exp Mol Pathol.

2.28

山东省立医院等

58

Hsa_circ_0069094抑制基因抑制乳腺癌细胞的增殖、迁移、侵袭和糖酵解,同时通过miR-661 / HMGA1轴诱导细胞凋亡

Hsa_circ_0069094 knockdown inhibits cell proliferation, migration, invasion and glycolysis, while induces cell apoptosis by miR-661/HMGA1 axis in breast cancer

Anticancer Drugs.

2.26

威海市中心医院等

59

CircRASSF2通过调节miR-195-5p / FZD4轴介导Wnt /β-catenin信号传导途径的活性,从而促进结直肠癌的增殖和转移。

CircRASSF2 facilitates the proliferation and metastasis of colorectal cancer by mediating the activity of Wnt/β-catenin signaling pathway by regulating the miR-195-5p/FZD4 axis

Anticancer Drugs.

2.26

浙江省台州医院等

60

通过RNA测序鉴定肥厚性瘢痕中关键的非编码RNA和mRNA

Identification of crucial noncoding RNAs and mRNAs in hypertrophic scars via RNA-sequencing

FEBS Open Bio.

2.231

北京301医院等

61

环状RNA circ_0062389通过miR-1179 /高迁移率组框1轴调节甲状腺乳头状癌的进展

Circular RNA circ_0062389 modulates papillary thyroid carcinoma progression via the miR-1179/high mobility group box 1 axis

Bioengineered.

2.205

大连医科大学附属第一医院等

62

环状RNA hsa_circ_0000117通过调节microRNA-337-3p /信号转导子和激活因子来促进胃癌细胞的增殖和侵袭

Circular RNA hsa_circ_0000117 accelerates the proliferation and invasion of gastric cancer cells by regulating the microRNA-337-3p/signal transducer and activator of transcription 3 axis

Bioengineered.

2.205

上海东方医院等

63

氮不足条件下玉米幼苗circRNA的鉴定与鉴定

Identification and characterization of circRNAs in maize seedling under deficient nitrogen

Plant Biol (Stuttg).

2.167

四川农业大学等

64

阻断circ-CNST可通过circ-CNST-miR-578-LDHA / PDK1 ceRNA网络抑制骨肉瘤细胞的恶性行为并抑制糖酵解

Blocking circ-CNST suppresses malignant behaviors of osteosarcoma cells and inhibits glycolysis through circ-CNST-miR-578-LDHA/PDK1 ceRNA networks

J Orthop Surg Res.

1.777

恩施州中心医院等

65

CircRNA ZNF609通过调节miR-145 / STMN1轴促进鼻咽癌的血管生成

CircRNA ZNF609 promotes angiogenesis in nasopharyngeal carcinoma by regulating miR-145/STMN1 axis

Kaohsiung J Med Sci.

1.737

昆明医科大学附属第一医院等

66

circ-KEL在急性粒细胞白血病中的表达及其在白血病细胞中的调控机制

[Expression of circ-KEL in acute myeloid leukemia and its regulatory mechanisms in leukemic cells]

Zhonghua Xue Ye Xue Za Zhi

0

江苏省人民医院等

67

[Hsa_circ_0006948通过调节miR-490-3p靶标ATG7的表达来调节骨肉瘤的增殖、迁移和侵袭]

[Hsa_circ_0006948 regulates the proliferation, migration and invasion in osteosarcoma by regulation of the expression of miR-490-3p target ATG7]

Zhonghua Zhong Liu Za Zhi

0

郑州大学附属肿瘤医院等

68

沉默circRNA ABCB10表达对结直肠癌细胞生物学特性的影响

[Effects of silencing circRNA ABCB10 expression on biological properties of colorectal cancer cells]

Zhonghua Zhong Liu Za Zhi

0

河南省人民医院等

69

长非编码RNA的核功能成为人们关注的焦点

The nuclear functions of long noncoding RNAs come into focus

Noncoding RNA Res

0

重庆大学等

 

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