欢迎各位来到“circRNA研究报道汇总”栏目，本期从pubmed中检索收集最新发布的circRNA文献共计107篇，下面我们一起来看看，circRNA研究最近有哪些新进展。
检索式：(circRNA[Title/Abstract]) OR Circular RNA[Title/Abstract]
1.设计小分子化合物在癌症治疗中调节非编码RNAs的策略
标题：Designing strategies of small-molecule compounds for modulating non-coding RNAs in cancer therapy
杂志：J Hematol Oncol
影响因子：17.388
通讯作者：刘博教授和Yi Chen（四川大学华西医院）
非编码RNA (ncRNAs)被定义为一类从基因组转录而不编码蛋白质的RNA分子，如microRNAs、长非编码RNAs、环状RNAs和piRNAs。近年来，越来越多的证据表明，基于其复杂的空间结构和在癌症治疗中的生物功能，ncRNAs成为调控几种小分子化合物的潜在药物靶点。因此，本文重点总结了一些新的设计策略，如高通量筛选方法、小分子芯片方法、基于结构的设计方法、表型筛选方法、基于片段的设计方法和药物验证方法。基于上述方法，双酚a、米托蒽醌、依诺沙星等一系列具有代表性的小分子化合物已被证实在不同类型的人类癌症中调控或选择性靶向ncRNAs。总的来说，这些鼓舞人心的发现将为开发更多的新途径，利用小分子药物对ncRNAs进行药理调节，以用于未来的癌症治疗提供线索。
设计小分子化合物调控癌症ncRNAs策略的利弊
2. 环状RNA Cwc27通过抑制Pur-α活性参与阿尔茨海默病的发病机制
标题：Circular RNA Cwc27 contributes to Alzheimer’s disease pathogenesis by repressing Pur-α activity
杂志：Cell Death Differ
影响因子：15.828
通讯作者：王昊教授和陈红专教授（上海交通大学医学院）
环状RNAs (circRNAs)因参与多种生物学过程和涉及多种疾病而受到越来越多的关注。尽管阿尔茨海默病(AD)的差异表达circRNA图谱已经建立，但在基因表达和疾病相关认知方面，与AD直接相关的关键环状RNAs的精确特征和功能尚不清楚。在本文中，作者筛选并鉴定了circCwc27是一种与AD相关的新型环状RNAs。CircCwc27是一种神经元中富含的环状RNAs，在大脑中大量表达，在AD小鼠和患者中显著上调。如图1所示，敲除circCwc27显著改善APP/PS1小鼠认知功能障碍。敲除circCwc27显著改善AD相关病理特征。在机制上，作者排除了miRNA海绵机制，重点研究了环状RNAs – RNA结合蛋白(RBP)相互作用在AD中的重要作用。CircCwc27直接结合于富含嘌呤元素的结合蛋白A (Pur-α)，增加了胞浆中Pur-α的保留，并抑制Pur-α招募到一组AD基因的启动子，包括淀粉样前体蛋白(APP)，多巴胺受体D1 (Drd1)，蛋白磷酸酶1，调节抑制剂亚基1b (Ppp1r1b)，神经营养酪氨酸激酶，受体，type 1 (Ntrk1)和LIM同源框8 (Lhx8)。circCwc27的下调增强了Pur-α与这些启动子结合的亲和力，导致Pur-α靶基因转录的改变。此外，Pur-α过表达在很大程度上抑制了circCwc27的表达，从而阻止了Aβ沉积和认知能力下降。总之，本研究结果表明，circRNAs -蛋白相互作用的显著功能，circCwc27通过与调节蛋白Pur-α相结合，可能在AD发病机制中发挥关键作用，并代表了一个有临床翻译潜力的有前景的AD治疗靶点。
图1. 敲除circCwc27可改善APP/PS1小鼠的认知能力下降
3. circRNAome图谱显示circFgfr2通过反馈回路调节肌生成和肌肉再生
标题：circRNAome profiling reveals circFgfr2 regulates myogenesis and muscle regeneration via a feedback loop
杂志：J Cachexia Sarcopenia Muscle
影响因子：12.910
通讯作者：唐中林研究员（中国农业科学院深圳农业基因组研究所）
背景：环状RNAs (circRNAs)是一类由共价闭合环形成的新型非编码RNAs，在许多生物过程中发挥着关键作用。已经报道了几种与肌生成相关的环状RNAs。然而，circRNAs在肌生成和骨骼肌发育过程中的动态表达、功能和机制仍不清楚。
方法：利用RNA测序(RNA-seq)和微阵列数据集对骨骼肌发育和肌源性分化过程中的circRNAome动态景观进行分析。生物信息学分析用于描述circRNAome并识别与肌生成相关的候选环状RNAs。通过Bulk和单细胞RNA-seq鉴定circFgfr2的下游基因和通路。主要的成肌细胞细胞C2C12细胞和动物模型被用来评估的功能和机制circFgfr2在肌细胞生成和肌肉再生RT-qPCR体外或体内,免疫印迹,dual-luciferase活动分析,RNA免疫沉淀反应,RNAfluorescence原位杂交,染色质免疫沉淀反应。
结果：作者对猪骨骼肌27个发育阶段的动态circRNAome进行了分析，检测到52 918个高可信度环状RNAs。其中2916个环状RNAs在人类、小鼠和猪中是保守的，包括4个环状RNAs (circFgfr2、circQrich1、circMettl9和circCamta1)，它们在不同的肌生成系统中存在差异表达(|log2 fold change| > 1和调整后的P值< 0.05)。作者进一步关注了一种由成纤维细胞生长因子受体2 (Fgfr2)基因产生的保守环状RNAs，称为circFgfr2，研究发现该环状RNAs抑制成肌细胞增殖，促进分化和骨骼肌再生。在机制上，circFgfr2作为miR-133的海绵，调控丝裂原活化蛋白激酶激酶20 (Map3k20)基因和JNK/MAPK通路。重要的是，JNK/MAPK通路下游的转录因子Kruppel like factor 4 (Klf4)直接结合到circFgfr2的启动子上，并通过miR-133/Map3k20/JNK/Klf4自动调节反馈回路影响其表达。RNA结合蛋白G3BP应激颗粒组装因子1 (G3bp1)抑制了circFgfr2的生成。
结论：本研究为骨骼肌的研究提供了一个全面的circRNA资源。如图2所示，circFgfr2的功能和机制分析揭示了一个由circRNA介导的调节肌生成和肌肉再生的自调节反馈回路，这为进一步理解circRNAs的调控机制提供了新的视角。
图2. circFgfr2在调节骨骼肌发育过程中的作用机制
文献列表
| 序号 | 主要内容 | 论文标题 | 杂志 | IF | 单位 |
| 1 | 设计小分子化合物在癌症治疗中调节非编码RNAs的策略 | Designing strategies of small-molecule compounds for modulating non-coding RNAs in cancer therapy | J Hematol Oncol | 17.388 | 四川大学华西医院 |
| 2 | 环状RNA Cwc27通过抑制Pur-α活性参与阿尔茨海默病的发病机制 | Circular RNA Cwc27 contributes to Alzheimer’s disease pathogenesis by repressing Pur-α activity | Cell Death Differ | 15.828 | 上海交通大学医学院 |
| 3 | circRNAome分析显示circFgfr2调控myog | circRNAome profiling reveals circFgfr2 regulates myog | J Cachexia Sarcopenia Muscle | 12.910 | 中国农业科学院 |
| 4 | 骨骼肌中的微蛋白:肌肉生理学的隐藏钥匙 | Microproteins in skeletal muscle: hidden keys in muscle physiology | J Cachexia Sarcopenia Muscle | 12.910 | Carlos Chagas研究所 |
| 5 | 肿瘤中基于RNA的诊断标志物的发现和治疗靶点的研究进展 | Review: RNA-based diagnostic markers discovery and therapeutic targets development in cancer | Pharmacol Ther | 12.310 | 南京中医药大学 |
| 6 | 用于自定义环状RNA功能预测的生物信息学软件 | CRAFT: a bioinformatics software for custom prediction of circular RNA functions | Brief Bioinform | 11.622 | 帕多瓦大学 |
| 7 | 环状RNA Cdyl通过诱导M1巨噬细胞极化和M1型炎症促进腹主动脉瘤形成 | Circular RNA Cdyl promotes abdominal aortic aneurysm formation by inducing M1 macrophage polarization and M1-type inflammation | Mol Ther | 11.454 | 南方医科大学南方医院 |
| 8 | CircZNF652通过靶向miR-452-5p/JAK2信号通路促进过敏性气道上皮杯状细胞化生 | CircZNF652 promotes the goblet cell metaplasia by targeting the miR-452-5p/JAK2 signaling pathway in allergic airway epithelia | J Allergy Clin Immunol | 10.793 | 浙江大学医学院 |
| 9 | 基于荧光纸的超灵敏双型RNA检测及胃癌准确筛查的分析装置 | Fluorescent paper-based analytical devices for ultra-sensitive dual-type RNA detections and accurate gastric cancer screening | Biosens Bioelectron | 10.618 | 南京林业大学，新不伦瑞克大学 |
| 10 | crh-1基因中circrna的缺失延长了秀丽隐杆线虫的平均寿命 | Loss of circRNAs from the crh-1 gene extends the mean lifespan in Caenorhabditis elegans | Aging Cell | 9.304 | 内华达大学生物系 |
| 11 | 缺氧诱导的ebv-circLMP2A通过KHSRP/VHL/HIF1α/VEGFA途径促进ebv相关胃癌血管生成 | Hypoxia-induced ebv-circLMP2A promotes angiogenesis in EBV-associated gastric carcinoma through the KHSRP/VHL/HIF1α/VEGFA pathway | Cancer Lett | 8.679 | 中山大学附属第三医院 |
| 12 | “环状RNA ciRS-7通过作为miR-876-5p海绵增强MAGE-A家族表达来加速ESCC进展”的勘误[Cancer Lett. 426 (2018) 37-46] | Corrigendum to “Circular RNA ciRS-7 accelerates ESCC progression through acting as a miR-876-5p sponge to enhance MAGE-A family expression” [Cancer Lett. 426 (2018) 37-46] | Cancer Lett | 8.679 | 河北医科大学 |
| 13 | 环状RNA测序显示血清外泌体环状RNA面板用于高级别星形细胞瘤的诊断 | Circular RNA Sequencing Reveals Serum Exosome Circular RNA Panel for High-Grade Astrocytoma Diagnosis | Clin Chem | 8.327 | 中南大学 |
| 14 | “The circular RNA TLK1通过TNF信号通路靶向miR-214/RIPK1加剧心肌缺血/再灌注损伤”的勘误[Free – Radic.]医学杂志。第155(2020)，69-80页] | Corrigendum to ‘The circular RNA TLK1 exacerbates myocardial ischemia/reperfusion injury via targeting miR-214/RIPK1 through TNF signaling pathway’ [Free Radic. Biol. Med. 155 (2020), 69-80] | Free Radic Biol Med | 7.376 | 河南省人民医院 |
| 15 | hsa_circ_0003410通过miR-139-3p/CCL5轴增加M2/M1巨噬细胞比例，从而促进肝细胞癌进展 | hsa_circ_0003410 promotes hepatocellular carcinoma progression by increasing the ratio of M2/M1 macrophages through the miR-139-3p/CCL5 axis | Cancer Sci | 6.716 | 苏州大学第一附属医院 |
| 16 | 环状RNA circGLIS3通过miR-1273f/SKP1/Cyclin D1轴促进膀胱癌增殖 | Circular RNA circGLIS3 promotes bladder cancer proliferation via the miR-1273f/SKP1/Cyclin D1 axis | Cell Biol Toxicol | 6.691 | 广西医科大学 |
| 17 | 环状和长链非编码RNAs在皮肤黑色素瘤中的多效性作用 | The pleiotropic roles of circular and long noncoding RNAs in cutaneous melanoma | Mol Oncol | 6.603 | 萨莱诺大学医学院 |
| 18 | 骨关节炎年回顾:遗传学，基因组学，表观遗传学 | Osteoarthritis year in review: genetics, genomics, epigenetics | Osteoarthritis Cartilage | 6.576 | 英国纽卡斯尔大学 |
| 19 | 子宫颈癌非编码RNA – EZH2调控机制的研究现状 | Non-coding RNAs-EZH2 regulatory mechanisms in cervical cancer: The current state of knowledge | Biomed Pharmacother | 6.529 | 同德医院妇科 |
| 20 | 甲状腺癌的分子机制:竞争性内源性RNA (ceRNA)的观点 | Molecular mechanisms of thyroid cancer: A competing endogenous RNA (ceRNA) point of view | Biomed Pharmacother | 6.529 | 郑州大学 |
| 21 | circSKA3作为miR-6796-5p的海绵，通过调节基质金属蛋白酶9的表达与缺血性卒中的预后相关 | circSKA3 acts as a sponge of miR-6796-5p to be associated with outcomes of ischemic stroke by regulating matrix metalloproteinase 9 expression | Eur J Neurol | 6.089 | 南通大学附属医院神经内科 |
| 22 | 环状RNA检测方法综述 | Circular RNA detection methods: A minireview | Talanta | 6.057 | 武汉大学中南医院药剂科 |
| 23 | CircSCAPER通过miR-140-3p/EZH2轴参与il -1β诱导的体外骨关节炎 | CircSCAPER contributes to IL-1β-induced osteoarthritis in vitro via miR-140-3p/EZH2 axis | Bone Joint Res | 5.853 | 拉萨市人民医院骨科 |
| 24 | 纠正:环状RNA ciRS-7作为miR-1299的ceRNA维持转移表型到目标MMPs | Correction: Circular RNA ciRS-7 Maintains Metastatic Phenotypes as a ceRNA of miR-1299 to Target MMPs | Mol Cancer Res | 5.852 | |
| 25 | 环状RNAs在脊髓损伤中的作用研究进展 | An update on the roles of circular RNAs in spinal cord injury | Mol Neurobiol | 5.590 | 青岛市中心医院 |
| 26 | 环状RNA circCSPP1通过海绵吸光miR-431，调控ROCK1和ZEB1，促进结肠癌的发生发展 | Circular RNA circCSPP1 promotes the occurrence and development of colon cancer by sponging miR-431 and regulating ROCK1 and ZEB1 | J Transl Med | 5.531 | 苏州大学第一附属医院 |
| 27 | 脑脊液源性环状RNAs在肺腺癌脑转移患者中的临床应用 | Clinical utility of cerebrospinal fluid-derived circular RNAs in lung adenocarcinoma patients with brain metastases | J Transl Med | 5.531 | 广东省人民医院 |
| 28 | 外显子-内含子环状RNA circRNF217通过降低miR-130-3p功能促进硬骨鱼的先天免疫和抗菌活性 | Exon-Intron Circular RNA circRNF217 Promotes Innate Immunity and Antibacterial Activity in Teleost Fish by Reducing miR-130-3p Function | J Immunol | 5.422 | 上海海洋大学 |
| 29 | 环状RNA hector 1通过促进大肠杆菌的分泌缓解溃疡性结肠炎 | Circular RNA HECTD1 Mitigates Ulcerative Colitis by Promoting E | Inflamm Bowel Dis | 5.325 | 中南大学湘雅医院 |
| 30 | 在朱砂叶螨中，环状RNA circ1-3p作为miR-1-3p的竞争性RNA参与了Cyflumetofen的耐药性 | Circular RNA, circ1-3p, is Involved in Cyflumetofen Resistance by Acting as a Competitive RNA against miR-1-3p in Tetranychus cinnabarinus | J Agric Food Chem | 5.279 | 西南大学 |
| 31 | 雌激素受体β通过改变circPHACTR4/miR-34b-5p/c-Myc信号通路增加透明细胞肾细胞癌干细胞的表型 | Estrogen receptor beta increases clear cell renal cell carcinoma stem cell phenotype via altering the circPHACTR4/miR-34b-5p/c-Myc signaling | FASEB J | 5.191 | 河北医科大学 |
| 32 | n6 -甲基腺苷依赖的circGARS修饰作为一种新的角色，通过NF-κB/A20轴促进SLE进展 | N6-methyladenosine-dependent modification of circGARS acts as a new player that promotes SLE progression through the NF-κB/A20 axis | Arthritis Res Ther | 5.156 | 第三军医大学 |
| 33 | 环状RNAs的翻译证据有限，或mRNA对应物在造血末期的翻译调节 | Circular RNAs exhibit limited evidence for translation, or translation regulation of the mRNA counterpart in terminal hematopoiesis | RNA | 4.942 | 阿姆斯特丹大学 |
| 34 | circRNA在癌症中的新功能和作用 | Emerging functions and roles of circRNAs in cancer | Epigenomics | 4.778 | 山东大学齐鲁医院血液科 |
| 35 | CircRNA-WNK2作为miR-328a-3p的ceRNA，促进雄性大鼠松果体中AANAT的表达 | CircRNA-WNK2 Acts as a ceRNA for miR-328a-3p to Promote AANAT Expression in the Male Rat Pineal Gland | Endocrinology | 4.736 | 吉林大学实验动物学系 |
| 36 | ceRNA网络的综合分析，以确定与透明细胞肾癌的预后、总生存率和免疫浸润相关的基因 | Comprehensive analysis of ceRNA networks to determine genes related to prognosis, overall survival, and immune infiltration in clear cell renal carcinoma | Comput Biol Med | 4.589 | 德黑兰医科大学癌症研究所癌症研究中心 |
| 37 | 在非小细胞肺癌中，Circ_0072088基因敲低有助于顺铂敏感性，并通过miR-944/LASP1轴抑制肿瘤进展 | Circ_0072088 knockdown contributes to cisplatin sensitivity and inhibits tumor progression by miR-944/LASP1 axis in non-small cell lung cancer | J Gene Med | 4.565 | 中国医科大学第四附属医院第一肺科 |
| 38 | CircFAM53B通过海绵吸波miR-532-3p激活c-MET/PI3K/AKT通路，促进胶质瘤的增殖和转移 | CircFAM53B promotes the proliferation and metastasis of glioma through activating the c-MET/PI3K/AKT pathway via sponging miR-532-3p | Cell Cycle | 4.534 | 中国药科大学生命科学与技术 |
| 39 | 冠心病高血压患者环形与线形ANRIL的表达比 | Expression ratio of circular to linear ANRIL in hypertensive patients with coronary artery disease | Sci Rep | 4.379 | 伊朗设拉子医科大学 |
| 40 | Circ-SNAP47 (hsa_circ_0016760)和miR-625-5p是WEE1的调节因子，通过ceRNA通路调控ddp耐受NSCLC细胞的化疗耐药、生长和侵袭 | Circ-SNAP47 (hsa_circ_0016760) and miR-625-5p are regulators of WEE1 in regulation of chemoresistance, growth and invasion of DDP-tolerant NSCLC cells via ceRNA pathway | Environ Toxicol | 4.119 | 长江大学附属仙桃第一人民医院 |
| 41 | 环状RNA circ_0008360通过调节miR-135b-5p/HDAC4轴抑制类风湿性关节炎成纤维细胞样滑膜细胞的增殖、迁移和炎症，并促进细胞凋亡 | Circular RNA circ_0008360 Inhibits the Proliferation, Migration, and Inflammation and Promotes Apoptosis of Fibroblast-Like Synoviocytes by Regulating miR-135b-5p/HDAC4 Axis in Rheumatoid Arthritis | Inflammation | 4.092 | 湖北医科大学太和医院骨科 |
| 42 | 来自ADSCs的外泌体通过传递Circ-Fryl和调控miR-490-3p/SIRT3通路来减弱脓毒症诱导的肺损伤 | Exosomes Derived from ADSCs Attenuate Sepsis-Induced Lung Injury by Delivery of Circ-Fryl and Regulation of the miR-490-3p/SIRT3 Pathway | Inflammation | 4.092 | 南京医科大学附属上海总医院 |
| 43 | 环状RNA – miRNA- mRNA网络在成骨细胞分化中的调控作用 | A regulatory role of circRNA-miRNA-mRNA network in osteoblast differentiation | Biochimie | 4.079 | SRM科学技术研究所工程技术学院生物技术系 |
| 44 | 茶树叶斑病病原体茶树叶斑病感染后环状RNAs在茶叶中的功能注释 | Functional Annotation of circRNAs in Tea Leaves After Infection by the Tea Leaf Spot Pathogen, Lasiodiplodia theobromae | Phytopathology | 4.025 | 贵州大学 |
| 45 | Circ_0001588通过海绵吸收miR-1281上调ERBB4促进胶质瘤恶性进展 | Circ_0001588 Upregulates ERBB4 to Promote Glioma Malignant Progression Through Sponging miR-1281 | Neurotox Res | 3.911 | 襄阳第一人民医院 |
| 46 | 在图卷积网络上使用新的节点分类和链接预测模型预测CircRNA疾病相关性 | Predicting CircRNA disease associations using novel node classification and link prediction models on Graph Convolutional Networks | Methods | 3.608 | 中国科学院，乔治亚州立大学 |
| 47 | 图卷积网络方法发现与疾病相关的circRNA-miRNA-mRNA轴 | Graph convolutional network approach to discovering disease-related circRNA-miRNA-mRNA axes | Methods | 3.608 | 四川大学 |
| 48 | 环状RNA circSLC8A1通过靶向miR-214-5p/CDC27轴抑制胶质瘤细胞的增殖和侵袭 | Circular RNA circSLC8A1 inhibits the proliferation and invasion of glioma cells through targeting the miR-214-5p/CDC27 axis | Metab Brain Dis | 3.584 | 山西医科大学运城中心医院 |
| 49 | 环状RNA circ_0070441通过miR-626/IRS2轴调控SH-SY5Y细胞中MPP +触发的神经毒性作用 | Circular RNA circ_0070441 regulates MPP +-triggered neurotoxic effect in SH-SY5Y cells via miR-626/IRS2 axis | Metab Brain Dis | 3.584 | 宁夏回族自治区人民医院神经内科 |
| 50 | Circ_0057583通过调节miR-204-5p/NR4A1轴促进脑微血管内皮细胞损伤 | Circ_0057583 facilitates brain microvascular endothelial cell injury through modulating miR-204-5p/NR4A1 axis | Metab Brain Dis | 3.584 | 郑州大学华中阜外医院，河南省人民医院 |
| 51 | circHECTD1基因下调可抑制氧-葡萄糖剥夺和再灌注诱导的内皮-间质转化 | Knockdown of circHECTD1 inhibits oxygen-glucose deprivation and reperfusion induced endothelial-mesenchymal transition | Metab Brain Dis | 3.584 | 华南大学衡阳医学院附属长沙中心医院 |
| 52 | circ_009773在纳米氧化钕诱导DNA损伤中的功能和调控网络的鉴定 | Identification of the function and regulatory network of circ_009773 in DNA damage induced by nanoparticles of neodymium oxide | Toxicol In Vitro | 3.500 | 包头医学院公共卫生学院 |
| 53 | 敲低circ-RAD23B可通过miR-142-3p/MAP4K3轴抑制非小细胞肺癌进展 | Knockdown of circ-RAD23B inhibits non-small cell lung cancer progression via the miR-142-3p/MAP4K3 axis | Thorac Cancer | 3.500 | 福建省肿瘤医院、福建医科大学肿瘤医院 |
| 54 | CircHIPK3通过调节miR-346/KCMF1通路参与人绒毛滋养细胞的生长、迁移和侵袭 | CircHIPK3 contributes to human villous trophoblast growth, migration and invasion via modulating the pathway of miR-346/KCMF1 | Placenta | 3.481 | 烟台中医医院妇科 |
| 55 | 环状RNA在环孢素a诱导大鼠心脏毒性中的潜在作用 | Potential role of circular RNA in cyclosporin A-induced cardiotoxicity in rats | J Appl Toxicol | 3.446 | 哈尔滨医科大学 |
| 56 | Hsa_circ_0003195作为胃癌诊断和预后的生物标志物 | Hsa_circ_0003195 as a biomarker for diagnosis and prognosis of gastric cancer | Int J Clin Oncol | 3.402 | 宁波大学 |
| 57 | circRNA是心血管疾病治疗的潜在靶点 | circRNA is a potential target for cardiovascular diseases treatment | Mol Cell Biochem | 3.396 | 青岛大学附属医院 |
| 58 | 智人环状RNA 0003602 (Hsa_circ_0003602)通过调节miR-502-5p/IGF1R轴加速急性髓系白血病的致瘤性 | Homo sapiens circular RNA 0003602 (Hsa_circ_0003602) accelerates the tumorigenicity of acute myeloid leukemia by modulating miR-502-5p/IGF1R axis | Mol Cell Biochem | 3.396 | 宁波市第一医院 |
| 59 | 注意:沉默环状RNA circ_0010729可以通过上调microRNA-145-5p来保护人心肌细胞免受缺氧-葡萄糖剥夺诱导的损伤 | Retraction Note to: Silencing circular RNA circ_0010729 protects human cardiomyocytes from oxygen-glucose deprivation-induced injury by up-regulating microRNA-145-5p | Mol Cell Biochem | 3.396 | 济宁医学院附属医院 |
| 60 | 环状RNA circ_0048764通过调控microRNA-1296-5p/tripartite motif containing 14 axis促进乳腺癌的发生发展 | Circular RNA circ_0048764 promotes the development of breast cancer by regulating microRNA-1296-5p/tripartite motif containing 14 axis | Bioengineered | 3.269 | 襄阳市中心医院普外科 |
| 61 | Circ_0019693通过调控microrna -942-5p靶向purkinje细胞蛋白4在骨质疏松的发生过程中促进骨髓间质干细胞的成骨分化并促进成骨耦合血管生成 | Circ_0019693 promotes osteogenic differentiation of bone marrow mesenchymal stem cell and enhances osteogenesis-coupled angiogenesis via regulating microRNA-942-5p-targeted purkinje cell protein 4 in the development of osteoporosis | Bioengineered | 3.269 | 山西医科大学第二医院骨科 |
| 62 | 环状RNA hsa_circ_0032683通过海绵作用microRNA-338-5p抑制肝细胞癌的进展 | Circular RNA hsa_circ_0032683 inhibits the progression of hepatocellular carcinoma by sponging microRNA-338-5p | Bioengineered | 3.269 | 东南大学 |
| 63 | 环状RNA hsa_circ_0001658通过microRNA-182/ ras相关蛋白rabbit -10信号轴调控胃癌细胞凋亡和自噬 | Circular RNA hsa_circ_0001658 regulates apoptosis and autophagy in gastric cancer through microRNA-182/Ras-related protein Rab-10 signaling axis | Bioengineered | 3.269 | 南昌大学 |
| 64 | hsa_circRNA_102049通过调节Reelin基因的表达介导了肝细胞癌细胞对sorafenib的敏感性 | The hsa_circRNA_102049 mediates the sorafenib sensitivity of hepatocellular carcinoma cells by regulating Reelin gene expression | Bioengineered | 3.269 | 中国医科大学附属肿瘤医院 |
| 65 | 环状RNA circ_0001955通过microRNA-655-3p上调碱性神经酰胺酶3的表达，促进肝细胞癌的发生 | Circular RNA circ_0001955 promotes hepatocellular carcinoma tumorigenesis by up-regulating alkaline ceramidase 3 expression through microRNA-655-3p | Bioengineered | 3.269 | 郑州大学第一附属医院 |
| 66 | 通过microRNA-145/gasdermin A轴敲除circ_0071269可以保护糖尿病性心肌病的损伤 | CircularRNA circ_0071269 knockdown protects against from diabetic cardiomyopathy injury by microRNA-145/gasdermin A axis | Bioengineered | 3.269 | 郑州大学第一附属医院 |
| 67 | CircRNA_0001795海绵miRNA-339-5p调节yes相关蛋白1的表达并减轻骨质疏松症的进展 | CircRNA_0001795 sponges miRNA-339-5p to regulate yes-associated protein 1 expression and attenuate osteoporosis progression | Bioengineered | 3.269 | 湖北医科大学 |
| 68 | 环状RNA SOX5促进肝细胞癌的增殖，抑制细胞凋亡 | Circular RNA SOX5 promotes the proliferation and inhibits the apoptosis of the hepatocellular carci | Bioengineered | 3.269 | 西安医科大学第一附属医院 |
| 69 | 敲低环状RNA toumess -like激酶1可减轻大脑中动脉闭塞小鼠的缺血性卒中以及氧-葡萄糖剥夺和再氧诱导的N2a细胞损伤 | Knockdown of circular RNA tousled-like kinase 1 relieves ischemic stroke in middle cerebral artery occlusion mice and oxygen-glucose deprivation and reoxygenation-induced N2a cell damage | Bioengineered | 3.269 | 内蒙古自治区人民医院神经外科 |
| 70 | 沉默环状RNAPTPN12可通过靶向microRNA-21-5p激活Wnt信号通路促进瘢痕疙瘩成纤维细胞的生长 | Silencing circular RNAPTPN12 promoted the growth of keloid fibroblasts by activating Wnt signaling pathway via targeting microRNA-21-5p | Bioengineered | 3.269 | 金华光复肿瘤医院肿瘤外科 |
| 71 | Circ-CUL2/microRNA-888-5p/RB1CC1轴通过抑制细胞进展参与NSCLC对顺铂的耐药 | Circ-CUL2/microRNA-888-5p/RB1CC1 axis participates in cisplatin resistance in NSCLC via repressing cell advancement | Bioengineered | 3.269 | 中国医学科学院肿瘤医院胸外科 |
| 72 | Circular RNA Rbms1通过调控miR-92a/BCL2L11信号通路抑制心肌缺血再灌注损伤的发生 | Circular RNA Rbms1 inhibited the development of myocardial ischemia reperfusion injury by regulating miR-92a/BCL2L11 signaling pathway | Bioengineered | 3.269 | 南京医科大学附属南京第一医院检验科 |
| 73 | 环状RNA hsa_circ_0006091作为肝细胞癌的一种新的生物标志物 | Circular RNA hsa_circ_0006091 as a novel biomarker for hepatocellular carcinoma | Bioengineered | 3.269 | 安徽医科大学 |
| 74 | Circular RNA_0033596通过microRNA-217-5p / cl胞内通道4轴加重氧化性低密度脂蛋白诱导的内皮细胞损伤 | Circular RNA_0033596 aggravates endothelial cell injury induced by oxidized low-density lipoprotein via microRNA-217-5p /chloride intracellular channel 4 axis | Bioengineered | 3.269 | 武汉大学人民医院 |
| 75 | 环状RNA溶血磷脂酸受体3 (circ-LPAR3)增强卵巢癌对顺铂的耐药性 | Circular RNA lysophosphatidic acid receptor 3 (circ-LPAR3) enhances the cisplatin resistance of ovarian cancer | Bioengineered | 3.269 | 广西中医药大学，广西医科大学第一附属医院 |
| 76 | Hsa_circ_0006677通过作为miR-1245a海绵在非小细胞肺癌中调节特殊的AT-rich结合蛋白2介导的肿瘤抑制效应 | Hsa_circ_0006677 regulates special AT-rich binding protein-2-mediated tumor-suppressive effect via functioning as a miR-1245a sponge in non-small cell lung cancer | Bioengineered | 3.269 | 中国北京民航总医院胸外科 |
| 77 | 环状RNA circ_0000518通过microRNA-1225-3p/SRY-box转录因子4途径促进乳腺癌进展 | Circular RNA circ_0000518 promotes breast cancer progression through the microRNA-1225-3p/SRY-box transcription factor 4 pathway | Bioengineered | 3.269 | 邯郸市中心医院肝胆外科 |
| 78 | 环状RNA circ_UBAP2通过调节microRNA miR-637/高迁移率组盒(HMGB) 2轴促进骨肉瘤的进展 | Circular RNA circ_UBAP2 facilitates the progression of osteosarcoma by regulating microRNA miR-637/high-mobility group box (HMGB) 2 axis | Bioengineered | 3.269 | 郑州大学 |
| 79 | 外泌体circPLK1的上调通过miR-1294/高迁移率组蛋白A1轴促进非小细胞肺癌的发生 | Upregulation of exosomal circPLK1 promotes the development of non-small cell lung cancer through the miR-1294/ high mobility group protein A1 axis | Bioengineered | 3.269 | 蚌埠医学院第一附属医院胸外科 |
| 80 | 消耗mmu_circ_0001751 (circular RNA Carm1)通过与microRNA-3098-3p结合调控酰基辅酶a合成酶长链家族成员4，保护急性脑梗死损伤 | Depletion of mmu_circ_0001751 (circular RNA Carm1) protects against acute cerebral infarction injuries by binding with microRNA-3098-3p to regulate acyl-CoA synthetase long-chain family member 4 | Bioengineered | 3.269 | 成都市第三人民医院神经内科 |
| 81 | 糖尿病肾病中钠-葡萄糖共转运蛋白2抑制剂达格列菌素处理的人近端肾小管上皮细胞中环状RNA和功能竞争性内源性RNA网络的鉴定 | Identification of circular RNAs and functional competing endogenous RNA networks in human proximal tubular epithelial cells treated with sodium-glucose cotransporter 2 inhibitor dapagliflozin in diabetic kidney disease | Bioengineered | 3.269 | 郑州大学第一附属医院 |
| 82 | CircRTN4IP1通过海绵吸除miR-541-5p诱导HIF1A的产生，调控肝内胆管癌的恶性进展 | CircRTN4IP1 regulates the malignant progression of intrahepatic cholangiocarcinoma by sponging miR-541-5p to induce HIF1A production | Pathol Res Pract | 3.250 | 新疆医科大学 |
| 83 | Circ-SWT1通过miR-192-5p/SOD2轴改善心肌细胞h2o2诱导的凋亡、氧化应激和内质网应激 | Circ-SWT1 Ameliorates H 2 O 2-Induced Apoptosis, Oxidative Stress and Endoplasmic Reticulum Stress in Cardiomyocytes via miR-192-5p/SOD2 Axis | Cardiovasc Toxicol | 3.231 | 哈尔滨医科大学第四附属医院心内科 |
| 84 | 环状RNA:在鼻咽癌中的功能和机制 | Circular RNAs: Functions and mechanisms in nasopharyngeal carcinoma | Head Neck | 3.147 | 中国医学科学院，复旦大学 |
| 85 | 环状RNAs 0000515和0011385作为胰管腺癌疾病监测和判断预后的潜在生物标志物 | circular RNAs 0000515 and 0011385 as potential biomarkers for disease monitoring and determining prognosis in pancreatic ductal adenocarcinoma | Oncol Lett | 2.967 | 华中科技大学同济医学院附属协和医院 |
| 86 | CircRNA_0044556通过海绵miR – 145和调节NRAS降低了三阴性乳腺癌细胞对阿霉素的敏感性 | CircRNA_0044556 diminishes the sensitivity of triple negative breast cancer cells to adriamycin by sponging miR 145 and regulating NRAS | Mol Med Rep | 2.952 | 华北理工大学唐山市人民医院 |
| 87 | Circ_0114427通过NF-κB通路调节miR-495-3p/TRAF6，促进lps诱导的脓毒性急性肾损伤 | Circ_0114427 promotes LPS-induced septic acute kidney injury by modulating miR-495-3p/TRAF6 through the NF-κB pathway | Autoimmunity | 2.815 | 湖北医科大学襄阳第一人民医院 |
| 88 | Circ-METTL15通过调控miR-1299/PDL1轴参与肺癌的增殖、转移、免疫逃逸和抑制凋亡 | Circ-METTL15 contributes to the proliferation, metastasis, immune escape and restrains apoptosis in lung cancer by regulating miR-1299/PDL1 axis | Autoimmunity | 2.815 | 吉林省肿瘤医院 |
| 89 | Hsa_circ_0074032作为microRNA-198诱饵，通过提高同源框A1的表达来促进前列腺癌的进展 | Hsa_circ_0074032 promotes prostate cancer progression through elevating homeobox A1 expression by serving as a microRNA-198 decoy | Andrologia | 2.775 | 中国深圳市龙华区中心医院泌尿外科 |
| 90 | 鉴定血浆hsa_circ_0000190和0001649作为预测口腔鳞状细胞癌患者复发和治疗反应的生物标志物 | Identification of plasma hsa_circ_0000190 and 0001649 as biomarkers for predicting the recurrence and treatment response of patients with oral squamous cell carcinoma | J Chin Med Assoc | 2.743 | 台北医科大学附属医院 |
| 91 | 环状RNA circCTNNA1在骨关节炎和海绵组织miR-29a中下调，以抑制脂多糖诱导的滑膜细胞凋亡 | Circular RNA circCTNNA1 is downregulated in osteoarthritis and sponges miR-29a to suppress LPS-induced apoptosis of synoviocytes | Immunopharmacol Immunotoxicol | 2.730 | 齐齐哈尔市第一医院风湿病免疫科 |
| 92 | CircRNA Circ-CCND1通过调控miR-497-5p/HMGA2轴加重肝细胞癌的发生 | CircRNA Circ-CCND1 Aggravates Hepatocellular Carcinoma Tumorigenesis by Regulating the miR-497-5p/HMGA2 Axis | Mol Biotechnol | 2.695 | 云南省第三人民医院消化内科 |
| 93 | hsa_circ_000839和hsa_circ_0005986在乳腺癌中的潜在作用 | Potential roles of hsa_circ_000839 and hsa_circ_0005986 in breast cancer | J Clin Lab Anal | 2.352 | 伊朗法沙医学科学大学 |
| 94 | Circ_0002577/miR-126-5p/MACC1轴通过调节子宫内膜癌细胞的增殖、迁移、侵袭和凋亡促进子宫内膜癌的进展 | Circ_0002577/miR-126-5p/MACC1 axis promotes endometrial carcinoma progression by regulation of proliferation, migration, invasion, and apoptosis of endometrial carcinoma cells | Arch Gynecol Obstet | 2.344 | 西安医科大学，陕西省人民医院 |
| 95 | PCGEM1通过海绵吸波miR-506上调TRIAP1，促进前列腺癌的增殖、迁移和侵袭 | PCGEM1 promotes proliferation, migration and invasion in prostate cancer by sponging miR-506 to upregulate TRIAP1 | BMC Urol | 2.264 | 黑龙江省红十字会森工总医院 |
| 96 | 在肝细胞癌中，环状RNA circ_0073181通过miR-548p调控蛋白酪氨酸磷酸酶受体E型参与肿瘤的发生 | Circular RNA circ_0073181 contributes to tumorigenesis by regulating protein tyrosine phosphatase receptor type E via miR-548p in hepatocellular carcinoma | Anticancer Drugs | 2.248 | 山西医科大学第三医院感染科 |
| 97 | Circ_0001658通过miR-409-3p/TWIST1轴调控非小细胞肺癌对吉非替尼的耐药性 | Circ_0001658 regulates gefitinib resistance of non-small cell lung cancer through miR-409-3p/TWIST1 axis | Anticancer Drugs | 2.248 | 宁夏医科大学，银川市口腔医院 |
| 98 | Circ_0009910作为miR-361-3p海绵，通过调节SNRPA促进胃癌的增殖、转移和糖酵解 | Circ_0009910 Serves as miR-361-3p Sponge to Promote the Proliferation, Metastasis, and Glycolysis of Gastric Cancer via Regulating SNRPA | Biochem Genet | 1.890 | 仙桃市第一人民医院胃肠外科 |
| 99 | Circ-NUP214通过miR-15a-5p调控HK2的表达促进甲状腺乳头状癌的发生 | Circ-NUP214 Promotes Papillary Thyroid Carcinoma Tumorigenesis by Regulating HK2 Expression Through miR-15a-5p | Biochem Genet | 1.89 | 西南医科大学附属医院，四川省肿瘤医院 |
| 100 | Circ_0072995通过调控miR-122-5p/SLC1A5轴促进卵巢癌进展 | Circ_0072995 Promotes Ovarian Cancer Progression Through Regulating miR-122-5p/SLC1A5 Axis | Biochem Genet | 1.890 | 四川省肿瘤医院 |
| 101 | Hsa_circ_0074371通过miR-582-3p/LRP6轴调控滋养细胞的增殖、凋亡、迁移和侵袭 | Hsa_circ_0074371 Regulates Proliferation, Apoptosis, Migration, and Invasion via the miR-582-3p/LRP6 Axis in Trophoblast Cells | Biochem Genet | 1.890 | 日照居县人民医院产科 |
| 102 | Circ-TFF1通过调控miR-338-3p/FGFR1轴促进乳腺癌的发展 | Circ-TFF1 Facilitates Breast Cancer Development via Regulation of miR-338-3p/FGFR1 Axis | Biochem Genet | 1.890 | 咸宁中医院超声科 |
| 103 | Hsa_circ_0006404和hsa_circ_0000735通过调节p-GP表达调控卵巢癌对多西他赛治疗的反应 | Hsa_circ_0006404 and hsa_circ_0000735 Regulated Ovarian Cancer Response to Docetaxel Treatment via Regulating p-GP Expression | Biochem Genet | 1.890 | 陕西中医药大学附属医院妇产科 |
| 104 | 胎盘转录组测序结合生物信息学预测与w | Placental transcriptome sequencing combined with bioinformatics predicts potential genes and circular RNAs associated w | J Obstet Gynaecol Res | 1.730 | 广西医科大学 |
| 105 | 穿心莲内酯通过调节circ_Rapgef1/miR-383-3p/NLRP3信号轴抑制骨关节炎进展 | Andrographolide suppresses osteoarthritis progression by regulating circ_Rapgef1/miR-383-3p/NLRP3 signaling axis | Transpl Immunol | 1.708 | 文登市骨科医院骨 |
| 106 | 环状RNAs在肝癌中的新作用 | Emerging roles of circular RNAs in liver cancer | JHEP Rep | Not Found | 法国雷恩大学 |
| 107 | 合成温石棉纳米载体递送circPRMT5 siRNA治疗膀胱癌 | Treatment of bladder cancer by geoinspired synthetic chrysotile nanocarrier-delivered circPRMT5 siRNA | Biomater Res | Not Found | 中南大学湘雅第三医院 |