欢迎各位来到“circRNA研究报道汇总”栏目，本期从pubmed中检索收集最新发布的circRNA文献共计103篇，下面我们一起来看看，circRNA研究最近有哪些新进展。
检索式：(circRNA[Title/Abstract]) OR Circular RNA[Title/Abstract]
杂志：Nat Rev Clin Oncol
影响因子：66.675
通讯作者：Jørgen Kjems和Lasse S. Kristensen（奥尔胡斯大学）
在过去十年中，环状RNAs（CircRNAs）已成为一大类主要的非编码RNA分子，其中许多通过不同的作用机制在癌症的发展和进展中发挥关键作用。CircRNAs通常具有组织和癌症特异性表达模式，积累的数据表明这些分子具有潜在的临床相关性和实用性。尤其是，CircRNAs作为诊断、预后和预测性生物标记物具有强大的潜力，其在血浆、唾液和尿液等液体活检样本中的可检测性突显了这一点。然而，需要解决CircRNAs检测和评估中的技术问题以及生物学知识缺口，以推进这一相对年轻的研究领域，并将CircRNAs推向临床实践的前沿。在此，作者回顾了目前关于circRNAs在癌症中的生物发生、调节和功能的知识，以及它们作为生物标记物、治疗剂和药物靶点的临床潜力。
CircRNAs在肿瘤中的作用机制
杂志：Mol Cancer
影响因子：27.401
通讯作者： 熊伟教授（中南大学肿瘤研究所）
背景：环状RNAs在肿瘤发生和发展中起着重要作用，但在鼻咽癌患者中尚未得到充分研究。
方法：通过RNA测序分析在NPC细胞中筛选环状RNA circCAMSAP1。通过实时定量聚合酶链反应（RT-qPCR）和原位杂交检测circCAMSAP1在鼻咽癌组织中的表达。采用创伤愈合、transwell、MTT和流式细胞术检测以及裸鼠肿瘤模型，在体外或体内研究 circCAMSAP1对鼻咽癌增殖和转移的影响。用质谱法筛选circCAMSAP1调控的下游蛋白。使用环状RNA免疫沉淀法和荧光素酶报告分析鉴定 circCAMSAP1和SERPINH1 mRNA之间的相互作用。SERPINH1和转录因子c-Myc之间的相互作用通过共免疫沉淀（Co-IP）和免疫荧光进行了验证。通过RT-qPCR和染色质免疫沉淀检测c-Myc对 circCAMSAP1产生的影响。最后，通过RT-qPCR和RNA免疫沉淀（RIP）研究了促进 circCAMSAP1产生的剪接因子。
结果：研究发现circCAMSAP1在鼻咽癌组织中高表达，促进了鼻咽癌的增殖和转移。此外，circCAMSAP1通过与SERPINH1的3′非翻译区（3′UTR）结合来提高SERPINH1 mRNA的稳定性，从而促进SERPINH1的表达。高表达的SERPINH1降低了c-Myc的泛素化降解率，导致肿瘤发生增加。同时，c-Myc与剪接因子10（SRSF10）协同作用，也能促进CAMSAP1前体mRNA转录和后剪接，形成circCAMSAP1产生的正反馈，导致鼻咽癌的增殖和转移。
结论：研究结果显示，circCAMSAP1通过结合SERPINH1的3’UTR促进NPC的增殖和转移，这表明circCAMSAP1-SERPINH1-c-Myc的正反馈可作为NPC患者的预后生物标志物或治疗靶点。
circCAMSAP1参与NPC作用机制
3. 实体瘤中不同环状RNA特征的表征
杂志：Mol Cancer
影响因子：27.401
通讯作者：李为民教授和彭勇教授（四川大学华西医院）
背景：环状RNAs（CircRNAs）在正常组织和癌组织中有差异表达，与肿瘤的发生和发展有关。然而，不同癌症类型中失调的CircRNAs的综合情况尚不清楚。
方法：在本研究中，作者对肿瘤组织及其邻近的正常样本（包括胶质母细胞瘤、食管鳞状细胞癌、肺腺癌、甲状腺癌、结直肠癌、胃癌和肝细胞癌）进行了核糖体转录组测序。CIRCexplorer2用于鉴定CircRNAs和失调的CircRNAs，基因由DESeq2包确定。通过逆转录和定量实时PCR检测hsa_circ_0072309（CircLIFR）的表达，并通过Transwell和伤口愈合实验检测其对细胞迁移的影响。通过尾静脉注射和脾脏注射分别用于肺和肝转移的小鼠模型，评估了CircLIFR在肿瘤转移中的作用。
结果：在七种实体瘤中发现了不同的circRNA表达特征，失调的circRNA表现出癌症特异性表达或在癌症中具有共同的表达特征。生物信息学分析表明，宿主基因和/或RNA结合蛋白的异常表达导致癌症中的环状RNA失调。最后，实验证实，在六种实体瘤中，CircLIFR表达下调，在体外显著抑制细胞迁移，在体内显著抑制肿瘤转移。
结论：研究结果为实体瘤中差异表达的CircRNAs提供了一个全面的图景，并强调CircRNAs广泛参与了癌症的发病机制。
七种实体瘤中差异表达CircRNAs的特征
文献列表
| 序号 | 主要内容 | 论文标题 | 杂志 | IF | 单位 |
| 1 | 环状RNAs在癌症和肿瘤学中的新作用 | The emerging roles of circRNAs in cancer and oncology | Nat Rev Clin Oncol | 66.675 | 奥尔胡斯大学 |
| 2 | 剪接因子衍生的环状RNA circCAMSAP1通过SERPINH1/c-Myc正反馈环加速鼻咽癌的发生 | Splicing factor derived circular RNA circCAMSAP1 accelerates nasopharyngeal carcinoma tumorigenesis via a SERPINH1/c-Myc positive feedback loop | Mol Cancer | 27.401 | 中南大学肿瘤研究所 |
| 3 | 实体肿瘤中明显环状RNA特征的表征 | Characterization of distinct circular RNA signatures in solid tumors | Mol Cancer | 27.401 | 四川大学华西医院呼吸与危重症医学科 |
| 4 | 肿瘤中调节EZH2信号的长、短非编码RNAs | The long and short non-coding RNAs modulating EZH2 signaling in cancer | J Hematol Oncol | 17.388 | 新加坡国立大学，萨班奇大学工程与自然科学学院，不列颠哥伦比亚大学 |
| 5 | CRISPR/Cas13效应子具有不同程度的脱靶效应，限制了它们在真核细胞中的应用 | CRISPR/Cas13 effectors have differing extents of off-target effects that limit their utility in eukaryotic cells | Nucleic Acids Res | 16.971 | 宾夕法尼亚大学 |
| 6 | circREEP3通过激活FKBP10转录和限制抗肿瘤免疫来驱动结直肠癌进展 | circREEP3 Drives Colorectal Cancer Progression via Activation of FKBP10 Transcription and Restriction of Antitumor Immunity | Adv Sci (Weinh) | 16.806 | 郑州大学 |
| 7 | 环状RNAs在生理学和非免疫疾病中的应用 | Circular RNAs in physiology and non-immunological diseases | Trends Biochem Sci | 13.807 | 中国科学技术大学第一附属医院，重庆大学生命科学学院 |
| 8 | 环状RNA circ-FoxO3通过诱导缺血/再灌注期间的自噬来减轻血脑屏障的损伤 | Circular RNA circ-FoxO3 attenuates blood-brain barrier damage by inducing autophagy during ischemia/reperfusion | Mol Ther | 11.454 | 暨南大学附属第一医院神经内科及脑卒中中心 |
| 9 | 小胶质细胞分泌含mir -146a-5p的外泌体来调节抑郁中的神经发生 | Microglia secrete miR-146a-5p-containing exosomes to regulate neurogenesis in depression | Mol Ther | 11.454 | 山东大学齐鲁医学院基础医学院生理学系 |
| 10 | 靶向环状RNA-MET通过抑制内皮顶端细胞特化来抗血管生成 | Targeting circular RNA-MET for anti-angiogenesis treatment via inhibiting endothelial tip cell specialization | Mol Ther | 11.454 | 复旦大学附属上海医学院 |
| 11 | exosomes衍生的circTRPS1促进膀胱癌微环境中的恶性表型和CD8+ T细胞衰竭 | Exosome-derived circTRPS1 promotes malignant phenotype and CD8+ T cell exhaustion in bladder cancer microenvironments | Mol Ther | 11.454 | 复旦大学附属华山医院 |
| 12 | circHIPK3调控miR-30c/DLL4轴对KSHV裂解复制至关重要 | Dysregulation of the miR-30c/DLL4 axis by circHIPK3 is essential for KSHV lytic replication | EMBO Rep | 8.807 | 英国利兹大学，南非罗氏大学 |
| 13 | mmu_circRNA_37492/hsa_circ_0012138可作为潜在的ceRNA减轻梗阻性肾纤维化 | The mmu_circRNA_37492/hsa_circ_0012138 function as potential ceRNA to attenuate obstructive renal fibrosis | Cell Death Dis | 8.469 | 中南大学湘雅二医院 |
| 14 | 环状RNA检测识别了常染色体显性遗传阿尔茨海默病特异性脑中的circPSEN1改变 | Circular RNA detection identifies circPSEN1 alterations in brain specific to autosomal dominant Alzheimer’s disease | Acta Neuropathol Commun | 7.801 | 华盛顿大学 |
| 15 | 环状RNA甲基化:肺纤维化的新转折 | CircRNA Methylation: A New Twist in Lung Fibrosis | Am J Respir Cell Mol Biol | 6.914 | 波士顿大学，阿拉巴马大学伯明翰分校 |
| 16 | 法布里病及相关表型患者血液中环状RNA为基础的生物标志物 | Circular RNA-based biomarkers in blood of patients with Fabry disease and related phenotypes | J Med Genet | 6.318 | 瑞士苏黎世大学 |
| 17 | 环状RNA circ_GLIS2抑制肝细胞癌的生长和转移 | Circular RNA circ_GLIS2 suppresses hepatocellular carcinoma growth and metastasis | Liver Int | 5.828 | 中南大学 |
| 18 | 外显子内含子环状RNA circRNF217通过降低miR-130-3p功能促进硬骨鱼的先天免疫和抗菌活性 | Exon-Intron Circular RNA circRNF217 Promotes Innate Immunity and Antibacterial Activity in Teleost Fish by Reducing miR-130-3p Function | J Immunol | 5.422 | 上海海洋大学 |
| 19 | 环状RNA ACTA1作为miR-199a-5p和miR-433的海绵，通过MAP3K11/MAP2K7/JNK通路调控牛成肌细胞的发育 | Circular RNA ACTA1 Acts as a Sponge for miR-199a-5p and miR-433 to Regulate Bovine Myoblast Development through the MAP3K11/MAP2K7/JNK Pathway | J Agric Food Chem | 5.279 | 西北农林科技大学，新疆农业大学 |
| 20 | eif4a3介导的circPRKCI表达通过调控WBP2和PI3K/AKT信号通路促进三阴性乳腺癌的进展 | EIF4A3-mediated circPRKCI expression promotes triple-negative breast cancer progression by regulating WBP2 and PI3K/AKT signaling pathway | Cell Death Discov | 5.241 | 同济大学医学院附属上海第十人民医院，徐州医科大学 |
| 21 | 环状RNA circBFAR通过调节miR-548b/FoxM1轴促进胶质母细胞瘤的进展 | Circular RNA circBFAR promotes glioblastoma progression by regulating a miR-548b/FoxM1 axis | FASEB J | 5.191 | 哈尔滨医科大学 |
| 22 | Circ_0000647通过调节miR-126-5p/TRAF3轴在糖氧剥夺再灌注诱导SK-N-SH细胞模型中促进细胞损伤 | Circ_0000647 promotes cell injury by modulating miR-126-5p/TRAF3 axis in oxygen-glucose deprivation and reperfusion-induced SK-N-SH cell model | Int Immunopharmacol | 4.932 | 海军医科大学附属长海医院 |
| 23 | circ_002172的促肿瘤作用通过miR-296-5p/CXCL12轴与乳腺癌诱导的免疫逃逸相关 | Tumor promoting effect of circ_002172 associates with induced immune escape in breast cancer via the miR-296-5p/CXCL12 axis | Int Immunopharmacol | 4.932 | 扬州江都人民医院普外科 |
| 24 | 在体外实验中，环状RNA circPTK2通过miR-136/NFIB信号通路调控三阴性乳腺癌细胞的迁移和侵袭 | Circular RNA circPTK2 modulates migration and invasion via miR-136/NFIB signaling on triple-negative breast cancer cells in vitro | Inflamm Res | 4.575 | 首都医科大学附属北京安贞医院普通外科 |
| 25 | circDPP4的沉默可通过调控miR-564/ZIC2轴抑制人前列腺癌的细胞进展并增强多西他赛的细胞毒性 | Silencing of circDPP4 suppresses cell progression of human prostate cancer and enhances docetaxel cytotoxicity through regulating the miR-564/ZIC2 axis | J Gene Med | 4.565 | 西安市人民医院(西安市第四医院)泌尿外科 |
| 26 | 环状RNA circ_0040823通过调控miR-516b/PTEN抑制急性髓系白血病细胞增殖并诱导凋亡 | Circular RNA circ_0040823 inhibits the proliferation of acute myeloid leukemia cells and induces apoptosis by regulating miR-516b/PTEN | J Gene Med | 4.565 | 贵州医科大学附属医院，遵义医学院附属医院 |
| 27 | Circ_0008035通过调控miR-1256/CEACAM6轴促进胃癌的进展 | Circ_0008035 promotes the progression of gastric cancer via the regulation of miR-1256/CEACAM6 axis | Cell Cycle | 4.534 | 河南科技大学第一附属医院 |
| 28 | Circ_0085315通过miR-1200/MAP3K1信号通路促进结肠癌细胞增殖、侵袭和迁移 | Circ_0085315 promotes cell proliferation, invasion, and migration in colon cancer through miR-1200/MAP3K1 signaling pathway | Cell Cycle | 4.534 | 宁波市第一医院老年病科 |
| 29 | 环状RNA hsa_circ_0000277促进食管鳞状细胞癌的肿瘤进展和DDP耐药 | Circular RNA hsa_circ_0000277 promotes tumor progression and DDP resistance in esophageal squamous cell carcinoma | BMC Cancer | 4.43 | 郑州大学附属肿瘤医院胸外科 |
| 30 | “环状RNA circZFPM2通过调节miR-205-5p/ZEB1信号通路促进子宫内膜异位症的上皮-间质转化”的勘误[细胞信号，87(2021)，110145] | Corrigendum to ‘Circular RNA circZFPM2 promotes epithelial-mesenchymal transition in endometriosis by regulating miR-205-5p/ZEB1 signalling pathway’ [Cellular Signalling, 87(2021), 110145] | Cell Signal | 4.315 | 中国医科大学附属盛京医院 |
| 31 | Circ_0007611刺激IL-1受体附属蛋白抑制滋养层细胞增殖，诱导细胞凋亡 | Circ_0007611 stimulates IL-1 receptor accessory protein to inhibit trophoblast cell proliferation and induce cell apoptosis | Biol Reprod | 4.285 | 济南市第四人民医院妇产科 |
| 32 | CircRNA circ_0000554通过调控miR-567促进卵巢癌侵袭和增殖 | CircRNA circ_0000554 promotes ovarian cancer invasion and proliferation by regulating miR-567 | Environ Sci Pollut Res Int | 4.223 | 胜利油田中心医院重症监护室 |
| 33 | 环状RNA circ_0008934通过调节miR-1305/TMTC3轴促进肝细胞癌的生长和转移 | Circular RNA circ_0008934 promotes hepatocellular carcinoma growth and metastasis through modulating miR-1305/TMTC3 axis | Hum Cell | 4.174 | 上海交通大学医学院同仁医院 |
| 34 | CircSmg5通过靶向miR-194-5p/Fzd6轴和β -catenin信号通路刺激骨髓间充质干细胞的成骨分化 | CircSmg5 stimulates the osteogenic differentiation of bone marrow mesenchymal stem cells by targeting the miR-194-5p/Fzd6 axis and beta-catenin signaling | Environ Toxicol | 4.119 | 南通大学附属医院骨科 |
| 35 | 一种新型环状RNA通过调节上铁作用使人表皮生长因子受体2阳性乳腺癌产生曲妥珠单抗耐药性 | A novel circular RNA confers trastuzumab resistance in human epidermal growth factor receptor 2-positive breast cancer through regulating ferroptosis | Environ Toxicol | 4.119 | 西安培华大学临床医学系 |
| 36 | 通过circRNA相关的CeRNA分析检测肝细胞癌的预后生物标志物 | Detection of Prognostic Biomarkers for Hepatocellular Carcinoma through CircRNA-associated CeRNA Analysis | J Clin Transl Hepatol | 4.108 | 青岛大学附属医院 |
| 37 | 【撤回】环状RNA CSNK1G1通过靶向miR – 4428/FUT2轴促进骨关节炎的进展 | [Retracted] Circular RNA CSNK1G1 promotes the progression of osteoarthritis by targeting the miR 4428/FUT2 axis | Int J Mol Med | 4.101 | 深圳市福田区风湿病医院 |
| 38 | CircPOSTN与KIF1B竞争miR-185-5p结合位点，促进胶质瘤的肿瘤发生 | CircPOSTN competes with KIF1B for miR-185-5p binding sites to promote the tumorigenesis of glioma | Brain Res Bull | 4.077 | 中国医科大学第四附属医院 |
| 39 | 非编码RNAs在氮杂胞苷治疗的骨髓增生异常综合征和急性髓系白血病伴骨髓增生异常相关改变中的疗效预测价值 | Noncoding RNAs and Their Response Predictive Value in Azacitidine-treated Patients With Myelodysplastic Syndrome and Acute Myeloid Leukemia With Myelodysplasia-related Changes | Cancer Genomics Proteomics | 4.069 | 捷克布拉格大学 |
| 40 | CircAXL敲低可通过释放miR-1306-5p抑制PDE4A减轻Aβ 1-42诱导的阿尔茨海默病神经毒性 | CircAXL Knockdown Alleviates Aβ 1-42-Induced Neurotoxicity in Alzheimer’s Disease via Repressing PDE4A by Releasing miR-1306-5p | Neurochem Res | 3.996 | 上海交通大学附属第六人民医院中医科 |
| 41 | 长链非编码RNAs和环状RNAs在骨再生中的作用:调节miRNAs功能 | The role of long non-coding RNAs and circular RNAs in bone regeneration: Modulating miRNAs function | J Tissue Eng Regen Med | 3.963 | 浙江中医药大学附属舟山中医医院 |
| 42 | Hsa_circ_0001020通过海绵组织miR-29c-3p促进MDM2表达，促进下肢深静脉血栓形成 | Hsa_circ_0001020 accelerates the lower extremity deep vein thrombosis via sponging miR-29c-3p to promote MDM2 expression | Thromb Res | 3.944 | 昆明医科大学 |
| 43 | 细胞内金黄色葡萄球菌感染人THP-1来源的巨噬细胞中环状RNAs的谱分析 | Profile analysis of circRNAs in human THP-1 derived macrophages infected with intracellular Staphylococcus aureus | Microb Pathog | 3.738 | 苏州大学第二附属医院 |
| 44 | circ_PRKDC/miR-20a-3p/RASA1轴调控HaCaT角化细胞迁移的识别 | Identification of the circ_PRKDC/miR-20a-3p/RASA1 axis in regulating HaCaT keratinocyte migration | Wound Repair Regen | 3.617 | 郑州大学第一附属医院整形外科 |
| 45 | 敲低circ_0007290可通过调节miR-496/PDCD4轴减轻氧-葡萄糖剥夺诱导的神经元损伤 | Knockdown of circ_0007290 alleviates oxygen-glucose deprivation-induced neuronal injury by regulating miR-496/PDCD4 axis | Metab Brain Dis | 3.584 | 高密市人民医院麻醉疼痛科 |
| 46 | eif4a3诱导的circCCNB1 (hsa_circ_0001495)通过miR-516b-5p和HuR相互作用提高CCND1，从而促进胶质瘤进展 | EIF4A3-induced circCCNB1 (hsa_circ_0001495) promotes glioma progression by elevating CCND1 through interacting miR-516b-5p and HuR | Metab Brain Dis | 3.584 | 北医科大学人民医院神经内科 |
| 47 | 表达谱和生物信息学分析表明，血浆外泌体环状RNAs可能参与了中国汉族人群的缺血性卒中 | Analysis of expression profiles and bioinformatics suggests that plasma exosomal circular RNAs may be involved in ischemic stroke in the Chinese Han population | Metab Brain Dis | 3.584 | 广西中医药大学第一附属医院，广西医科大学公共卫生学院 |
| 48 | 环状RNA PVT1通过海绵microRNA-199a-5p抑制肌腱干/祖细胞衰老 | Circular RNA PVT1 inhibits tendon stem/progenitor cell senescence by sponging microRNA-199a-5p | Toxicol In Vitro | 3.5 | 解放军总医院第四医疗中心 |
| 49 | CircRNA PRH1-PRR4通过sponge – miR-877-5p刺激RAB3D调控NSCLC的恶性进展 | CircRNA PRH1-PRR4 stimulates RAB3D to regulate the malignant progression of NSCLC by sponging miR-877-5p | Thorac Cancer | 3.5 | 东营市人民医院心胸外科 |
| 50 | 敲低circ-RAD23B可通过miR-142-3p/MAP4K3轴抑制非小细胞肺癌进展 | Knockdown of circ-RAD23B inhibits non-small cell lung cancer progression via the miR-142-3p/MAP4K3 axis | Thorac Cancer | 3.5 | 福建医科大学肿瘤医院放疗科 |
| 51 | 子痫前期的环状RNA表达谱和竞争性内源性RNA调控网络 | Circular RNA expression profile and competing endogenous RNA regulatory network in preeclampsia | Placenta | 3.481 | 四川大学华西第二医院妇产科 |
| 52 | Circ_0025039通过mir -636依赖的CORO1C调控，在非小细胞肺癌的进展中发挥致癌作用 | Circ_0025039 acts an oncogenic role in the progression of non-small cell lung cancer through miR-636-dependent regulation of CORO1C | Mol Cell Biochem | 3.396 | 中南大学湘雅医学院海口附属医院 |
| 53 | CircWHSC1通过miR-532-3p/LTBP2轴加速宫颈癌进展 | CircWHSC1 expedites cervical cancer progression via miR-532-3p/LTBP2 axis | Mol Cell Biochem | 3.396 | 中国医科大学盛京医院妇产科 |
| 54 | 环状RNA circ_0020014通过miR-613/ADAMTS5轴促进骨关节炎进展 | Circular RNA circ_0020014 contributes to osteoarthritis progression via miR-613/ADAMTS5 axis | Bosn J Basic Med Sci | 3.363 | 西安交通大学医学院附属西安宏辉医院骨科 |
| 55 | 环状RNA circ-HN1的下调通过miR-485-5p/GSK3A通路抑制胃癌的进展 | Downregulation of circular RNA circ-HN1 suppressed the progression of gastric cancer through the miR-485-5p/GSK3A pathway | Bioengineered | 3.269 | 柳州市人民医院 |
| 56 | 下调环状RNA hsa_circ_0005797通过调节microRNA-298/Catenin delta 1信号通路抑制子宫内膜癌 | Downregulated circular RNA hsa_circ_0005797 inhibits endometrial cancer by modulating microRNA-298/Catenin delta 1 signaling | Bioengineered | 3.269 | 河南科技大学附属第一医院 |
| 57 | 成纤维细胞外泌体通过circZFR靶向信号转导器和转录激活因子(STAT3)/核因子-κB (NF-κB)通路促进肝细胞癌对顺铂的化疗耐药 | Cancer-associated fibroblast exosomes promote chemoresistance to cisplatin in hepatocellular carcinoma through circZFR targeting signal transducers and activators of transcription (STAT3)/ nuclear factor -kappa B (NF-κB) pathway | Bioengineered | 3.269 | 南京医科大学第一附属医院，中国医学科学院 |
| 58 | 环状RNA HIPK3通过调节microRNA-338/叉头盒A1轴加重脓毒症诱导的急性肾损伤 | Circular RNA HIPK3 aggravates sepsis-induced acute kidney injury via modulating the microRNA-338/forkhead box A1 axis | Bioengineered | 3.269 | 湖州市第一人民医院 |
| 59 | 环状RNA CDK6通过海绵吸收miR-449a抑制宫颈癌的增殖和转移 | Circular RNA CDK6 suppresses cervical cancer proliferation and metastasis by sponging miR-449a | Bioengineered | 3.269 | 福建医科大学附属肿瘤医院妇科 |
| 60 | circRNA_FOXO3 rs12196996多态性和FOXO3 rs2232365多态性对重症监护室获得性脓毒症患者生存率和严重程度的影响 | Effect of circRNA_FOXO3 rs12196996 polymorphism and FOXO3 rs2232365 polymorphism on survival rate and severity of intensive care unit-acquired sepsis | Bioengineered | 3.269 | 温州市人民医院 |
| 61 | CircMMD_007通过microRNA-197-3p/蛋白酪氨酸磷酸酶非受体9轴在肺腺癌进展中促进致癌作用 | CircMMD_007 promotes oncogenic effects in the progression of lung adenocarcinoma through microRNA-197-3p/protein tyrosine phosphatase non-receptor type 9 axis | Bioengineered | 3.269 | 福建医科大学胜利临床医学院 |
| 62 | circRNA_0000285基因敲除可通过海绵吸收microRNA-654-3p抑制宫颈癌细胞活力，促进细胞凋亡 | circRNA_0000285 knockdown suppresses viability and promotes apoptosis of cervical cancer cells by sponging microRNA-654-3p | Bioengineered | 3.269 | 浙江省芷江市人民医院超声科 |
| 63 | 环状RNA circ_0068464联合microRNA-383调控Wnt/β-catenin通路，促进结直肠癌进展 | Circular RNA circ_0068464 combined with microRNA-383 regulates Wnt/β-catenin pathway to promote the progression of colorectal cancer | Bioengineered | 3.269 | 广西医科大学第四附属医院医学科学实验室 |
| 64 | Hsa_circ_0005230上调，通过调控miR-1299/RHOT1轴促进胃癌细胞侵袭和迁移 | Hsa_circ_0005230 is up-regulated and promotes gastric cancer cell invasion and migration via regulating the miR-1299/RHOT1 axis | Bioengineered | 3.269 | 中国医科大学第一附属医院 |
| 65 | 环状RNA VMA21通过靶向microRNA-497-5p/ cd2相关蛋白轴改善脓毒症大鼠肺损伤 | Circular RNA VMA21 ameliorates lung injury in septic rat via targeting microRNA-497-5p/CD2-associated protein axis | Bioengineered | 3.269 | 银川市人民医院急诊科 |
| 66 | 通过环状RNA hsa_circ_0000285调控microRNA miR-197-3p/CDC28蛋白激酶调控亚基1B (CKS1B)轴促进胶质瘤进展 | Regulation of microRNA miR-197-3p/CDC28 protein kinase regulatory subunit 1B (CKS1B) axis by Circular RNA hsa_circ_0000285 promotes glioma progression | Bioengineered | 3.269 | 湖北医科大学 |
| 67 | 环状RNA circ_0030018/miR-136/migration and invasion enhancer 1 (MIEN1)轴促进多囊卵巢综合征的进展 | The circular RNA circ_0030018/miR-136/migration and invasion enhancer 1 (MIEN1) axis promotes the progression of polycystic ovary syndrome | Bioengineered | 3.269 | 重庆市妇幼保健中心妇科 |
| 68 | 环状RNA PIP5K1A作为microRNA-552-3p海绵，通过Janus激酶1调控糖脂毒性诱导的胰腺INS-1 β细胞的炎症、氧化损伤 | Circular RNA PIP5K1A act as microRNA-552-3p sponge to regulates inflammation, oxidative damage in glucolipotoxicity-induced pancreatic INS-1 β-cells via Janus kinase 1 | Bioengineered | 3.269 | 郑州大学第一附属医院内分泌科 |
| 69 | CircRNA SOD2通过作为microRNA-2355-5p的竞争性内源性RNA，介导钙调素调控的spectrin相关蛋白-2，促进非小细胞肺癌的EMT进展 | CircRNA SOD2 motivates non-small cell lungs cancer advancement with EMT via acting as microRNA-2355-5p’s competing endogenous RNA to mediate calmodulin regulated spectrin associated proteins-2 | Bioengineered | 3.269 | 大连医科大学 |
| 70 | 环状RNA三重功能域通过调节microRNA-136-5p/烟酰胺磷酸核糖转移酶轴促进骨关节炎的发展 | Circular RNA triple functional domain promotes osteoarthritis’ development by modulating the microRNA-136-5p/Nicotinamide phosphoribosyltransferase axis | Bioengineered | 3.269 | 陕西中医药大学附属医院骨科 |
| 71 | 环状RNA-UBE2D2通过调节microRNA-376a-3p/真核翻译起始因子4γ2轴加速非小细胞肺癌细胞的增殖和转移 | Circular RNA-UBE2D2 accelerates the proliferation and metastasis of non-small cell lung cancer cells via modulating microRNA-376a-3p/Eukaryotic Translation Initiation Factor 4γ2 axis | Bioengineered | 3.269 | 常州市第二人民医院心胸外科 |
| 72 | 环状RNA SET结构域蛋白3通过调控microRNA-147a的表达，促进鼻咽癌增殖、顺铂耐药和雷帕霉素通路激活的蛋白激酶B /哺乳动物靶蛋白 | Circular RNA SET domain protein 3 promotes nasopharyngeal carcinoma proliferation, cisplatin resistance, and protein kinase B / mammalian target of rapamycin pathway activation by modulating microRNA-147a expression | Bioengineered | 3.269 | 青海省人民医院耳鼻咽喉科 |
| 73 | 环状RNA circHIPK3在糖尿病心肌病中下调，过表达circHIPK3可抑制PTEN，从而保护心肌细胞免受高糖诱导的细胞凋亡 | Circular RNA circHIPK3 is downregulated in diabetic cardiomyopathy and overexpression of circHIPK3 suppresses PTEN to protect cardiomyocytes from high glucose-induced cell apoptosis | Bioengineered | 3.269 | 鹤岗市宝泉岭中心医院心内科 |
| 74 | 环状RNA hsa_circ_0119412通过调控miR-1298-5p/锌指BED-type containing 3 (ZBED3)轴参与胃癌的发生 | Circular RNA hsa_circ_0119412 contributes to tumorigenesis of gastric cancer via the regulation of the miR-1298-5p/zinc finger BED-type containing 3 (ZBED3) axis | Bioengineered | 3.269 | 华中科技大学同济医学院 |
| 75 | 新型环状RNA HIPK3通过海绵吸除micro – RNA-124或micro – RNA-506/丙酮酸脱氢酶激酶2轴，加速肝细胞癌细胞的增殖和侵袭 | The novel circular RNA HIPK3 accelerates the proliferation and invasion of hepatocellular carcinoma cells by sponging the micro RNA-124 or micro RNA-506/pyruvate dehydrogenase kinase 2 axis | Bioengineered | 3.269 | 厦门大学中山医院肝胆胰外科 |
| 76 | 缺氧预处理的脂肪源间充质干细胞(ADSCs)外泌体形成的环状RNA mmu_circ_0001295可以改善脓毒症小鼠模型的预后，并抑制脓毒症诱导的肾损伤 | Circular RNA mmu_circ_0001295 from hypoxia pretreated adipose-derived mesenchymal stem cells (ADSCs) exosomes improves outcomes and inhibits sepsis-induced renal injury in a mouse model of sepsis | Bioengineered | 3.269 | 复旦大学浦东医学中心 |
| 77 | 状RNA hsa_circ_0008896通过hsa-miR-633/CDC20B(细胞分裂周期20B)轴促进血管平滑肌细胞增殖、迁移和侵袭，从而加速动脉粥样硬化 | Circular RNA hsa_circ_0008896 accelerates atherosclerosis by promoting the proliferation, migration and invasion of vascular smooth muscle cells via hsa-miR-633/CDC20B (cell division cycle 20B) axis | Bioengineered | 3.269 | 上海交通大学附属胸科医院 |
| 78 | 环状RNA midline-1 (circMID1)促进前列腺癌的增殖、迁移、侵袭和糖酵解 | Circular RNA midline-1 (circMID1) promotes proliferation, migration, invasion and glycolysis in prostate cancer | Bioengineered | 3.269 | 郑州大学第一附属医院 |
| 79 | Circular RNA-microRNA-mRNA network识别出circ_0007618和circ_0029426为肺腺癌新的有价值的生物标志物 | Circular RNA-microRNA-mRNA network identified circ_0007618 and circ_0029426 as new valuable biomarkers for lung adenocarcinoma | Bioengineered | 3.269 | 南京医科大学 |
| 80 | 环状RNA circRNA_0067934通过调节microRNA miR-7/ Wnt/β-catenin轴促进胶质瘤的发展 | Circular RNA circRNA_0067934 promotes glioma development by modulating the microRNA miR-7/ Wnt/β-catenin axis | Bioengineered | 3.269 | 扬州大学临床医学院 |
| 81 | 环状RNA Circ_0008043通过调节microRNA (miR)-326/RAB21轴促进肝细胞癌细胞的增殖和转移 | Circular RNA Circ_0008043 promotes the proliferation and metastasis of hepatocellular carcinoma cells by regulating the microRNA (miR)-326/RAB21 axis | Bioengineered | 3.269 | 深圳市第三人民医院 |
| 82 | 含有eps15同源结构域的环状RNA蛋白2通过与microRNA-3186-3p和forkhead box K1的串扰促进非小细胞肺癌的增殖、糖酵解，但抑制自噬 | Circular RNA Eps15-homology domain containing protein 2 motivates proliferation, glycolysis but refrains autophagy in non-small cell lung cancer via crosstalk with microRNA-3186-3p and forkhead box K1 | Bioengineered | 3.269 | 北京协和医学院 |
| 83 | 环状RNA F-circEA-2a在胃腺癌中表达增加，抑制过早的microRNA-3940-5p向成熟的microRNA-3940-5p的转变 | Circular RNA F-circEA-2a expression is increased in gastric adenocarcinoma and inhibits the transition from premature microRNA-3940-5p to mature microRNA-3940-5p | Bioengineered | 3.269 | 华中科技大学同济医学院附属普爱医院 |
| 84 | 环状RNA ZNF609通过海绵吸附microRNA-134-5p上调表皮生长因子受体，从而促进喉部鳞状细胞癌进展 | Circular RNA ZNF609 promotes laryngeal squamous cell carcinoma progression by upregulating epidermal growth factor receptor via sponging microRNA-134-5p | Bioengineered | 3.269 | 河北医科大学第二医院 |
| 85 | 环状RNA hsa_circ_0077837在非小细胞肺癌中上调，通过甲基化下调磷酸酶和紧张素同源物 | Circular RNA hsa_circ_0077837 is upregulated in non-small cell lung cancer to downregulate phosphatase and tensin homolog through methylation | Bioengineered | 3.269 | 山东大学齐鲁医院胸外科 |
| 86 | 环状RNA hector d1敲除可抑制转化生长因子-β/小母细胞对抗十pentaplegic (TGF-β/Smad)信号，以减少增生性瘢痕纤维化 | Circular RNA HECTD1 knockdown inhibits transforming growth factor-beta/ small mothers against decapentaplegic (TGF-β/Smad) signaling to reduce hypertrophic scar fibrosis | Bioengineered | 3.269 | 南京医科大学第一附属医院烧伤整形外科 |
| 87 | 环状RNA circ_0111277作为ceRNA，靶向miR-424-5p/NFAT5轴调控子痫前期滋养细胞的增殖、迁移和侵袭 | Circular RNA circ_0111277 Serves as ceRNA, Targeting the miR-424-5p/NFAT5 Axis to Regulate the Proliferation, Migration, and Invasion of Trophoblast Cells in Preeclampsia | Reprod Sci | 3.06 | 复旦大学附属中山医院青浦分院产科 |
| 88 | CircVMA21通过调控miR-7-5p/PPARA改善脂多糖(LPS)诱导的HK-2细胞损伤 | CircVMA21 ameliorates lipopolysaccharide (LPS)-induced HK-2 cell injury depending on the regulation of miR-7-5p/PPARA | Autoimmunity | 2.815 | 兰州大学第二医院 |
| 89 | Circ_0003645作为miR-335-5p海绵，通过上调NFIB促进弥漫性大b细胞淋巴瘤的生物学过程 | Circ_0003645 serves as miR-335-5p sponge to promote the biological process of diffuse large B-cell lymphoma by upregulating NFIB | Autoimmunity | 2.815 | 福建医科大学漳州附属医院 |
| 90 | Circ_0076305通过海绵吸波miR-411-5p和调节PGK1促进前列腺癌的发展 | Circ_0076305 facilitates prostate cancer development via sponging miR-411-5p and regulating PGK1 | Andrologia | 2.775 | 江南大学附属医院泌尿外科 |
| 91 | 蒙古马的快、慢肌纤维特异性表达谱受非编码RNA的影响 | Fast and slow myofiber-specific expression profiles are affected by noncoding RNAs in Mongolian horses | Comp Biochem Physiol Part D Genomics Proteomics | 2.674 | 内蒙古农业大学动物科学学院 |
| 92 | Circ_0008500基因敲除可通过miR-758-3p/PFN2轴提高乳腺癌的放射敏感性并抑制肿瘤发生 | Circ_0008500 Knockdown Improves Radiosensitivity and Inhibits Tumorigenesis in Breast Cancer Through the miR-758-3p/PFN2 Axis | J Mammary Gland Biol Neoplasia | 2.673 | 河北医科大学第四医院 |
| 93 | Circ_0020123通过消除mir -193a-3p介导的IRF4在非小细胞肺癌中的抑制而上调IRF4，从而调控自噬、糖酵解和恶性肿瘤 | Circ_0020123 regulates autophagy, glycolysis, and malignancy by upregulating IRF4 through eliminating miR-193a-3p-mediated suppression of IRF4 in non-small cell lung cancer | Neoplasma | 2.575 | 中山大学附属第六医院，广州医科大学附属肿瘤医院 |
| 94 | 环状RNA hsa_circRNA_102049通过结合和抑制miRNA-455-3p促进结直肠癌细胞迁移和侵袭 | Circular RNA, hsa_circRNA_102049, promotes colorectal cancer cell migration and invasion via binding and suppressing miRNA-455-3p | Exp Ther Med | 2.447 | 浙江大学第一附属医院肛管外科 |
| 95 | 玉米对伊朗花叶病毒感染反应的miRNAs特性研究 | Characterization of maize miRNAs responsive to maize Iranian mosaic virus infection | 3 Biotech | 2.406 | 设拉子大学农学院 |
| 96 | 环状RNA hsa_circ_0011385通过隔离miR-149-5p和增加PRDX6的表达来促进宫颈癌的进展 | Circular RNA hsa_circ_0011385 contributes to cervical cancer progression through sequestering miR-149-5p and increasing PRDX6 expression | Reprod Biol | 2.376 | 陕西省肿瘤医院 |
| 97 | circYap通过阻滞细胞周期抑制口腔鳞状细胞癌 | circYap inhibits oral squamous cell carcinoma by arresting cell cycle | Acta Odontol Scand | 2.331 | 河北中医药大学中西医结合学院 |
| 98 | 非编码RNAs在三阴性乳腺癌和四阴性乳腺癌中的功能意义和交叉交谈 | The functional significance and cross-talk of non-coding RNAs in triple negative and quadruple negative breast cancer | Mol Biol Rep | 2.316 | 韦洛尔理工学院生物科学与技术学院 |
| 99 | 环状RNA circPDSS1通过海绵吸收miR-502-3p和miR-4436a促进骨肉瘤进展 | Circular RNA circPDSS1 promotes osteosarcoma progression by sponging miR-502-3p and miR-4436a | Anticancer Drugs | 2.248 | 浙江大学医学院第二附属医院 |
| 100 | 通过靶向miR-489-3p降低CDK1的表达，抑制乳腺癌的发生，增强他莫西芬的敏感性 | CircCDK1 knockdown reduces CDK1 expression by targeting miR-489-3p to suppress the development of breast cancer and strengthen the sensitivity of Tamoxifen | Anticancer Drugs | 2.248 | 西安交通大学第二附属医院，陕西省肿瘤医院 |
| 101 | 利多卡因通过circITFG2/miR-1204/SOCS2轴阻碍结直肠癌进程 | Lidocaine hampers colorectal cancer process via circITFG2/miR-1204/SOCS2 axis | Anticancer Drugs | 2.248 | 前海人寿保险广州总医院 |
| 102 | Circ_0016760通过miR-876-3p/NOVA2轴作为非小细胞肺癌的癌症启动子 | Circ_0016760 Serves as a Cancer Promoter in Non-small Cell Lung Cancer Through miR-876-3p/NOVA2 Axis | Biochem Genet | 1.89 | 大连医科大学第二附属医院全科 |
| 103 | 环状非编码RNA circ_0007865是一种竞争性内源性RNA，靶向miR-214-3p/FKBP5轴调控脑微血管内皮细胞缺氧诱导的损伤 | Circular noncoding RNA circ_0007865, serves as a competing endogenous RNA, targeting the miR-214-3p/FKBP5 axis to regulate oxygen-glucose deprivation-induced injury in brain microvascular endothelial cells | Neuroreport | 1.837 | 东营市第二人民医院药剂科 |